Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, MiRNA-based therapy for Age-associated dementia and Alzheimer’s disease (AD): MiRNA-19b increases the expression of AGE receptor 1 (AGER1), the longevity-promoting gene Sirtuin-1 and decreases advanced glycation end products (AGEs) via down regulation of its target gene, 13/June/2015, 11.06 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that MiRNA-19b, by decreasing the expression of its target gene, it may: (1) increase the expression of AGE receptor 1 (AGER1); (2) increase the expression of longevity-promoting gene Sirtuin-1; and (3) decrease advanced glycation end products (AGEs). Thus, pharmacological formulations encompassing “MiRNA-19b activators” can be used to decrease ageing and increase the life-span of an individual.
Undisclosed information: How MiRNA-19b increases the expression of AGER1
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