Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, MiRNA-based therapy for Cancer: MiRNA-146b suppresses the expression of RNA polymerase I via down regulation of its target gene, 8/March/2015, 22.43, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that MiRNA-146b, by suppressing the expression of its target gene, it may increase the expression of RNA polymerase I. Thereby, it may increase the proliferation of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-146b activators” can be used to inhibit the progression of human cancers.
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* Research cooperation
Undisclosed information: How MiRNA-146b suppresses the expression of RNA polymerase I