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Idea Proposed/Formulated byDr L Boominathan Ph.D.

CitationBoominathan, MiRNA-based therapy for Chronic Myelogenous Leukemia (CML): MiRNA-373 eradicates CML leukemia stem cells via activation of p53, 11/October/2014, 05.07 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests that tumor suppressor MiRNA-373, by decreasing the expression of its target gene, it may increase the expression of guardian of the genome p53; and decrease the expression of immortality gene telomerase. Given that p53 is the most mutated tumor suppressor gene in human cancer, pharmacological formulations encompassing “MiRNA-373 or its activators may be used to eliminate CML leukemia stem cells.


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