Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, MiRNA-based therapy for Lifespan extension: Cell cycle-regulated protein E2F1 inhibits senescence and exends lifespan by down regulating the expression of ADCY5, 6/September/2014, 10.45 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that E2F1 extends lifespan by (1) suppressing the expression of ADCY5; and (2) increasing the expression of longevity-associated genes such as telomerase and Siruin-1. Thus, pharmacological formulations encompassing “E2F1 activator” may be used to (1) inhibit ageing process; (2) and extend lifespan.