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Idea Proposed/Formulated byDr L Boominathan Ph.D.

Significance: Cancer suppressor p53 is mutated in more than 50% of different human cancers.  This study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured by activating its “unmutated homologous proteins”, such as TAp73. MiRNA-214, by decreasing the expression of its target gene, it may increase the expression of p53 homologue TAp63γ. Thereby, it may promote tumor suppression. Together, this study suggests a therapeutic strategy as to how one can cure cancer, by activating an alternative cancer suppressor, with an miRNA-214. Thus, pharmacological formulations encompassing “MiRNA-214 activators”  can be used to inhibit the progression of human tumors, including p53-mutated human tumors.

Web: http://genomediscovery.org

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Amount: $ 500*

Undisclosed information: How MiRNA-214 increases the expression of TAp73

* Research cooperation

CitationBoominathan, Therapeutic insights into “awakening the sleeping angel” in p53-mutated human tumors: MiRNA-214 increases the expression of tumor suppressor p53 homologue TAp73 and inhibits tumorigenesis via down regulation of its target gene, 31/3/2015, 21.40, 31/3/2015, 21.36, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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