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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, MiRNA-based therapy for p53-mutated human tumors: MiRNA-429 increases the expression of p73 and inhibits tumorigenesis via down regulation of its target gene, 6/February/2015, 03.03 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that MiRNA-429, by decreasing the expression of its target gene, it may increase the expression of p53 homologue p73. Thereby, it may promote tumor suppression. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured; that is, by activating its un-mutated homologous proteins, such as p73. Thus, pharmacological formulations encompassing “MiRNA-429 activators”  can be used to inhibit the progression of human tumors, including p53-mutated human tumors

Amount: $ 500*

Undisclosed information: How MiRNA-429 increases the expression of p73

Web: http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

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