A recent study from the from the Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States of America shows that “High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4.“ This study was published in the 8 Feb’13 issue of the Journal “Molecular Medicine” by Drs. Bauer PM, Bauer EM and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based therapy for pulmonary hypertension: MiRNA-200c suppresses pulmonary hypertension via down regulation of its target gene. This study suggests, for the first time, that MiRNA-200c, by decreasing the expression of its target gene, may: (1) decrease Right ventricular systolic pressure, and (2) inhibit thickening of the pulmonary artery wall. Together, pharmacological formulations encompassing “MiRNA-200c or its activators“ may be used to treat patients suffering from pulmonary hypertension.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, MiRNA-based therapy for pulmonary hypertension: MiRNA-200c suppresses pulmonary hypertension via down regulation of its target gene, 12/March/2015, 11.21, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How MiRNA-200c stifles pulmonary hypertension