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A recent study from Howard Hughes Medical Institute, Center for Stem Cell Biology, NYU School of Medicine, 550 First Avenue, New York, USA has reported the role of Notch-regulated lncRNA LUNARI in Acute Leukemia. This study was published in the July 31  2014 Cell (I.F: >35; The number 1 journal in basic biology) by Prof  Iannis Aifantis, Thomas Trimarchi and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based treatment for Human Leukemia:MiRNA-139-5p  inhibits acute leukemia via down regulation of Notch-regulated pro-oncogenic lncRNA LUNAR1This study suggests that MiRNA-139-5p, by decreasing the expression of  Notch-1, lncRNA LUNAR1 and IGF1R mRNA, it may inhibit acute leukemia. Together, this study suggests that pharmacological formulations encompassing MiRNA-139-5p  or its activators may be used to treat patients  suffering from leukemia.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, MiRNA-based treatment for Human Leukemia:MiRNA-139-5p  inhibits acute leukemia via down regulation of Notch-regulated pro-oncogenic lncRNA LUNAR1, 31/August/2014,  16.18 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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