A recent study from the Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Goettingen, Germany shows that “Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease.” This study was published in the 5 Jan’13 issue of the journal EMBO Mol Medicine.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Alzheimer’s disease: c-Myc ameliorates cognitive deficits in Alzheimer’s disease patients via up regulation of its target gene
Significance:
Given that (1) in 2006, 26.6 million people worldwide’re afflicted by Alzheimer’s disease; (2) the number of cases diagnosed with Alzheimer’s disease may increase from 26.6 million people in 2006 to 106.4 million in 2050 worldwide; (3) Alzheimer’s disease is the forth leading cause of death in US in the elderly; (4) Alzheimer’s disease is the third most costly disease to treat only after cancer and coronary heart disease; and (5) US$80–100 billion spent in US in caring for patients diagnosed with Alzheimer’s disease, there is an urgent need to find: (1) a cheaper alternative to the existing expensive drugs; and (2) a side-effect-free natural product-based drug.
This study suggests, for the first time, that c-Myc, by increasing the expression of its target gene, it may decrease the expression of HDAC6. Thereby, it may ameliorates cognitive deficits in Alzheimer’s disease patients. Thus, pharmacological formulations encompassing “c-Myc activators” may be used to improve cognitive deficits in Alzheimer’s disease patients.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Molecular therapy for Alzheimer’s disease: c-Myc ameliorates cognitive deficits in Alzheimer’s disease patients via up regulation of its target gene, 6/June/2014, 10.47 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How c-Myc decreases HDAC6 expression