Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Molecular therapy for DM: 17α-E2 (an estrogen derivative) increases the expression of the stem cell protein Lin-28 via down regulation of its target gene , 08/September/2014, 06.11 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has recently been shown that Lin-28 promotes insulin sensitivity. This study suggests that 17α-E2 (an estrogen derivative), by suppressing thee expression of its target gene, it may up regulate the expression of Lin-28. Thus, pharmacological formulations encompassing ” 17α-E2 or its analogues“ may be used to treat DM.
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