Natural product-based therapy for DM: Mangiferin, a compound isolated from Mango, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 25/September/2014, 11.03 am

Natural product-based therapy for DM: Mangiferin, a compound isolated from Mango, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 25/September/2014, 11.03 am

Natural product-based therapy for DM: Mangiferin, a compound isolated from Mango, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 25/September/2014, 11.03 am 150 150

A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.”

This study was published in the June 26, 2014 Nature [I.F >35] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product-based therapy for DM: Mangiferin, a compound isolated from Mango, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1.  This study may suggest that Mangiferin, by up regulating its target gene, it may inhibit  gluconeogenesis and hyperglycemia. Together, this study suggests that pharmacological formulations encompassing Magniferin or its analogues”  can be used in the treatment of NIDDM.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., Molecular therapy for DM: Nitric oxide synthase-2 activators inhibit gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 25/September/2014, 11.03 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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