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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Significance: This study suggests, for the first time, that Roquin, by down regulation of its target gene, it may increase the expression of tumor suppressor CCM/KRIT1.  Thus, pharmacological formulations containing “Roquin activators” can be used in the treatment of human cancers.

To citeBoominathan,   Molecular therapy for Human Cancer: Roquin [RING finger and CCCH-type zinc finger domain-containing protein 1] increases the expression of  tumor suppressor CCM1/KRIT1 via down regulation of its target gene, 12/March/2015, 14.10,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Roquin increases the expression of CCM1/KRIT1

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