Molecular therapy for Hyperglycemia & T2DM: Antrodia salmonea increases the expression of AMPK(5′ adenosine monophosphate-activated protein kinase), decreases gluconeogenesis and fasting glucose level via up regulation of its target gene, 9/June/2015, 8.31 am

A recent study from the Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; & Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China shows that “Hepatic p38α regulates gluconeogenesis by suppressing AMPK.” This study was published in the 13 Jan 2015 issue of “Journal of Hepatolgy“[the no. 1 research journal in Hepatalogy with an impact factor of 10.4) by Prof Hao Ying, Yanyan Jing, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Molecular therapy for Hyperglycemia & T2DM: Antrodia salmonea increases the expression of AMPK (5′ adenosine monophosphate-activated protein kinase), decreases gluconeogenesis and fasting glucose level via up regulation of its target gene

Significance: 

Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; (3) DM is often associated with a number of other diseases such as hypertension, myocardial infarction, cardiac hypertrophy etc; and (4) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find better and cheaper drugs–with multifaceted effects–to treat Hyperglycemia & DM.

This study suggests, for the first time, that Antrodia salmonea, by increasing the expression of its target genes, it may increase the expression of AMPK.  Thereby, it may lower hepatic glucose production and plasma glucose levels. Thus, pharmacological formulations encompassing “Antrodia salmonea” may be used to treat DM.

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To cite: Boominathan,  Molecular therapy for Hyperglycemia & T2DM: Antrodia salmonea increases the expression of AMPK(5′ adenosine monophosphate-activated protein kinase), decreases gluconeogenesis and fasting glucose level via up regulation of its target gene, 9/June/2015, 8.30 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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