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Significance: This study suggests, for the first time, that p53, by suppressing the expression of its target gene, it may increase the expression of PDLIM5. Thereby, it may inhibit pulmonary hypertension. Together, pharmacological formulations encompassing “p53/PDLIM5 activators may be used to treat pulmonary arterial hypertension (PAH).

Amount: $ 500*

Undisclosed information: How p53  increases the expression of PDLIM5

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, Molecular therapy for Pulmonary Hypertension (PAH): Tumor suppressor p53 inhibits pulmonary hypertension via induction of PDLIM5, 4/February/2015,  23.20,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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