Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Natural product-based anti-cancer stem cell therapy: Agaricus blazei Murill, a medicinal mushroom, suppresses the expression of stem cell protein Oct-4 and increases the expression tumor suppressor genes via down regulation of its target gene, 30/January/20145, 18.26, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that Agaricus blazei Murill, by decreasing the expression of its target gene, it may suppress the expression of stem cell protein Oct-4 and increase the expression of tumor suppressor genes. Given that most of the human cancers relapse after chemotherapy because of the presence of cancer stem cells, this study suggests a therapeutic strategy as to how cancer stem cells can be eliminated from tumors. Thus, pharmacological formulations encompassing “Agaricus blazei Murill or small molecule compounds isolated from Agaricus blazei Murill” may be used to inhibit the progression of human tumors.
Amount: $ 500
Undisclosed information: How Agaricus blazei Murill increases the stability and activity of p73α
Web: http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
* Research cooperation