Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Significance: Curcumin, by increasing the expression of its target genes, it may decrease the expression of stem cell enriched protein, Oct4 and the cell cycle regulatory protein, Cyclin E. Thereby, it may inhibit stemness in head and neck squamous carcinoma. Thus, pharmacological formulations encompassing “Curcumin or its analogues” may be used to inhibit the progression of head and neck squamous carcinoma.
Undisclosed information: How Curcumin suppresses the expression of Oct4 and Cyclin E
Citation: Boominathan, L., Natural product-based anti-cancer stem cell therapy: Curcumin, the major component of turmeric, suppresses the expression of stem cell enriched protein, Oct4 and the cell cycle regulatory protein, Cyclin E via up regulation of its target gene, 6/May/2015, 23.02, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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