Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Isorhapontigenin, a byproduct of Piceatannol, may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 3/May/2015, 16.27, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that Isorhapontigenin, isolated from seeds of Passsion fruit, may extend the lifespan of an individual. It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that Isorhapontigenin, by increasing the expression of its target gene, it may suppress the expression of AT1R. And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decrease ageing ; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Isorhapontigenin or its analogues” may be used to extend the life-span of an individual.
Undisclosed information: How Isorhapontigenin suppresses the expression of angiotensin II type I receptor (AT1R)
