A recent study from the Institute for Cancer Research and CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Science, University of Science and Technology of China, Hefei 230027, China shows that “Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.” This study was published in the 10 October issue of 2014 Nature Communications by Prof Zhang, Ma, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Cancer: Agaricus blazei Murill (AbM) inhibits glycolysis and cancer progression via down regulation of PDK1.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, Natural product-based therapy for Cancer: Agaricus blazei Murill (AbM) inhibits glycolysis and cancer progression via down regulation of PDK1, 10/February/2015, 23.04, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that tumor suppressor Agaricus blazei Murill (AbM), by increasing the expression of its target gene, it may decrease the expression of PDK1. Thereby, it may inhibit aerobic glycolysis, or warburg effect, in cancer cells. Thus, pharmacological formulations encompassing “Agaricus blazei Murill“ may be used to stall the progression of Cancer.
Undisclosed information: How Agaricus blazei Murill (AbM) decreases the expression of PDK1