Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural product-based therapy for Cancer: Triptolide, a natural compound found in the herb Thunder of God vine, increases the expression of tumor suppressor LKB1 via down regulation of its target gene , 27/August/2014, 18.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: Triptolide, by suppressing the expression of its target miRNA, it may: (1) increase the expression of tumor suppressor LKB1; and (2) inhibit cancer stem cell proliferation. Thus, pharmacological formulations encompassing “Triptolide or its analogues” may be used to treat cancer.