A study from Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK shows that “MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer.” This study was published in the April 14, 2014 Cancer Cell by Prof. Dr Valeri N and others.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product-based therapy for Human cancers: Silvestrol, a compound isolated from the fruits and twigs of Aglaia foveolata, inhibits the expression of oncogenic MiRNA-135b via up regulation of its target gene. MiRNA-135b has been shown to promote colon cancer by (1) acting as a downstream effector of oncogenic pathways; and (2) inhibiting the expression of a number of tumor suppressor proteins. Based on this, we propose here a therapeutic strategy as to how one can cure colon cancers over-expressing miRNA-135. Taken together, this study suggests that pharmacological formulations encompassing “Silvestrol or its analogues” can be used in the treatment of colon cancers.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product-based therapy for Human cancers: Silvestrol, a compound isolated from the fruits and twigs of Aglaia foveolata, inhibits the expression of oncogenic MiRNA-135b via up regulation of its target gene, 2/August/2014, 6.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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