A recent study from the Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China shows that “Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling.” This study was published in the 1 September’13 issue of of the Journal “Cardiovascular Research” by Prof Lan HY, Wei LH, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for hypertensive cardiovascular diseases: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses Ang II-induced hypertensive cardiac remodelling via down regulation of its target gene. By treating patients suffering with hypertensive cardiovascular diseases, with Celastrol, one may prevent Ang II-induced hypertensive cardiac remodelling. Together, this study suggests, for the first time, that pharmacological formulations encompassing “Celastrol or its analogues” may be used to inhibit the progression of Ang II-induced hypertensive cardiac remodelling.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed information: How Celastrol inhibits Ang II-induced hypertensive cardiac remodelling
To cite: Boominathan, Natural product-based therapy for hypertensive cardiovascular diseases: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses Ang II-induced hypertensive cardiac remodelling via down regulation of its target gene, 31/March/2015, 23.24, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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