Natural product-based therapy for Metastatic tumors: Berberine suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 17/February/2015, 9.09 am

Natural product-based therapy for Metastatic tumors: Berberine suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 17/February/2015, 9.09 am

Natural product-based therapy for Metastatic tumors: Berberine suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 17/February/2015, 9.09 am 150 150

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product-based therapy for Metastatic tumors: Berberine suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 17/February/2015, 9.09 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests that Berberine, by suppressing the expression of its target gene, it may decrease the expression of PD-1.  Thereby, it may activate the immune system that inhibit tumor development. Thus, pharmacological formulations encompassing “Berberine or its analogues  may be used to inhibit the progression of tumors.

Amount: $ 500*

Undisclosed information: How Berberine suppresses the expression of PD-1

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