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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product-based therapy for Metastatic tumors:  Bicalutamide, an androgen receptor antagonist, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 24/February/2015, 18.48, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: It has recently been shown that blocking PD-1 with antibodies,  one could make tumors shrink. This study suggests, for the first time, that Bicalutamide, by suppressing the expression of its target geneit may decrease the expression of PD-1. Thereby, it may activate the immune system to inhibit tumor progressionThus, pharmacological formulations encompassing “Bicalutamide or its analogues  may be used to inhibit the progression of tumors.

Amount: $ 500*

Undisclosed information: How Bicalutamide suppresses the expression of PD-1

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