Natural product-based therapy for Metastatic tumors: BRCA1 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 7/March/2015, 15.56

Natural product-based therapy for Metastatic tumors: BRCA1 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 7/March/2015, 15.56

Natural product-based therapy for Metastatic tumors: BRCA1 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 7/March/2015, 15.56 150 150

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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Citation: Boominathan, L., Natural product-based therapy for Metastatic tumors: BRCA1 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 7/March/2015, 15.56, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. 

The study presented here suggests that BRCA1 , by decreasing the expression of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate the immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing “BRCA1  or its activators“ may be used to inhibit the progression of tumors.

Undisclosed information: How  BRCA1 suppresses the expression of PD-1

Web: http://genomediscovery.org

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