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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Natural product-based therapy for Metastatic tumors: Silvestrol, a compound isolated from the fruits of Aglaia foveolata, decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 6/March/2015, 6.54 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org


It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. 

The study presented here suggests that Silvestrol, by decreasing the expression of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate the immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing Silvestrol or its analogues may be used to inhibit the progression of tumors.

Amount: $ 500*

Undisclosed information: How  Silvestrol suppresses the expression of PD-1

Web: http://genomediscovery.org

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