Significance: It has been shown that muscle atrophy is associated with a number of disease conditions, including Cancer cachexia. This study suggests, for the first time, that Berberine, by increasing the expression of its target gene, it may decrease myostatin expression, increase MyoD expression and satellite cell proliferation and induce fiber hypertrophy. Thereby, it may inhibit muscle fiber atrophy during cancer cachexia and sepsis and promote muscle growth. Thus, pharmacological formulations encompassing “Berberine or its analogues” may be used to treat Cachexia.
Undisclosed information: How Berberine inhibits muscle atrophy and promotes muscle growth
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Natural product-based therapy for Muscle wasting and Cancer cachexia: Berberine, an isoquinoline derivative alkaloid isolated from medicinal herbs, inhibits muscle fiber atrophy during cancer cachexia and sepsis and promotes muscle growth via up regulation of its target gene, 4/May/2015, 9.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org