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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product-based therapy for p53-mutated human cancers: Sulindac, an anti-inflammatory drug, increases the expression of tumor suppressor p53 homologue TAp63 via down regulation of its target gene, 4/March/2015, 8.34 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that Sulindac, by suppressing the expression of its target geneit may increase the expression of TAp63. Thereby, it may inhibit tumor progressionThus, pharmacological formulations encompassing “Sulindac or its analogues”  may be used to inhibit the progression of tumors.

Amount: $ 300*

Undisclosed information: How Sulindac increases the expression of TAp63

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