A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: Fisetin, a flavonoid enriched in strawberries, Mangoes and Cucumber, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3
Significance: Fisetin, by increasing the expression of their target gene, it may decrease the expression of Notch3. Thus, pharmacological formulations encompassing “Fisetin or its activators” may be used to treat pulmonary arterial hypertension.
Undisclosed information: How Fisetin decreases the expression of Notch3
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product-based therapy for pulmonary arterial hypertension: Fisetin, a flavonoid enriched in strawberries, Mangoes and Cucumber, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 23/May/2015, 23.22, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
