A recent study from the Department of Systems Medicine, University of Tor Vergata, Italy shows that Mongersen, an oral SMAD7 antisense oligonucleotide, inhibits regional enteritis disease. This study was published in the 19 March 2015 issue of of the Journal “N. Engl. J. Med.” [I.F: 54.42] by Prof Pallone F., Monteleone G, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product–based therapy for regional enteritis disease: Oleic acid, the main component of Neem oil, increases the expression of immunosuppressive cytokine TGF-β1 and inhibits the progression of regional enteritis disease via up regulation of its target gene. By treating patients suffering with regional enteritis disease, with Oleic acid, one may increase the expression of immunosuppressive cytokine transforming growth factor β1 (TGF-β1) and suppress inflammation. Together, this study suggests, for the first time, that pharmacological formulations encompassing “Oleic acid or its analogues” may be used to inhibit the progression of regional enteritis disease.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed information: How Oleic acid inhibits the progression of regional enteritis disease
To cite: Boominathan, Natural product-based therapy for regional enteritis disease: Oleic acid, the main component of Neem oil, increases the expression of immunosuppressive cytokine TGF-β1 and inhibits the progression of regional enteritis disease via up regulation of its target gene, 31/March/2015, 22.25, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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