What we say:
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: α-lipoic acid, found in Broccoli, brussel sprouts, and kali among others, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene
From Significance of the study to Public health relevance:
Given that: (1) in any given year, nearly 20-30% of people are affected by Allergic Rhinitis; (2) most of the medications available today for allergic rhinitis treats only the symptoms, and provide temporary relief; (3) corticosteroid therapy for allergic rhinitis may have its own side effects; (4) the global economic cost spent in the treatment of allergic rhinitis is enormous, there is an urgent need to find: (i) a way to cure allergic rhinitis, without adverse side effects; (ii) a cheaper alternative to the existing expensive medications; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, allergic rhinitis.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, a natural product based therapy for Allergic Rhinitis. α-lipoic acid, by increasing the expression of its target genes, it may: (1) inhibit GM-CSF levels; (2) decrease IL13Rα1 expression; (3) suppress eotaxin expression; and (4) inhibit mucus production (fig 1).
Figure 1. α-lipoic acid inhibits the development and progression of Allergic Rhinitis via up regulation of its target gene
Thus, pharmacological formulations encompassing “α-lipoic acid or its analogues either alone or in combination with other drugs” may be used to control allergic rhinitis.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does α-lipoic acid decrease the expression of GM-CSF/L13Ra1/eotaxin to inhibit allergic rhinitis?
Amount: $50
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References:
Web: http://genomediscovery.org or http://newbioideas.com
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Natural product-derived therapy for Allergic rhinitis: α-lipoic acid, found in Broccoli, brussel sprouts, and kali among others, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 6/April/2017, 11.56 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org