Introduction: What they say:
A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71] by Prof and Dean of the Harvard Medical School Daley GQ, Zhu H, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Berberine, an isoquinoline derivative alkaloid isolated from many medicinal herbs, promotes an insulin-sensitized state via up-regulation of its target gene
Significance:
Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find a way to induce regeneration of adult β-cells that were lost in DM.
What is known?
Prof. Daley GQ and his team members had shown earlier that loss of Lin28 in muscles promotes insulin resistance and glucose intolerance.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, that Berberine, by increasing the expression of its target gene, it may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote youthful regenerative capacity; and (4) promote insulin sensitivity.
Figure 1. The chemical structure of Berberine. Berberine may promote insulin sensitivity via up regulation of reprogramming protein Lin-28
Figure 2. Berberine, found in Berberis, among others, functions as an antihyperglycemic agent.
Thus, pharmacological formulations encompassing “Berberine or its analogues either alone or in combination with other drugs” may be used to treat DM.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $ 50
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Undisclosed mechanistic information: How does Berberine promote insulin-sensitized state?
# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com/
Citation: Boominathan L, Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Berberine, an isoquinoline derivative alkaloid isolated from Berberis, Berberis aristata, Hydrastis canadensis (goldenseal), and Phellodendron amurense among others, promotes an insulin-sensitized state via up-regulation of its target gene, 11/February/2017, 10.09 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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