- A study from the Department of Neurology, Charité-Universitaetsmedizin Berlin, Berlin, Germany has reported that “An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.”
- This study was published in the 15 June 2012 Nature Neuroscience by Prof. Lehnardt S, Lehmann and others from the Department of Neurology, Charité-Universitaetsmedizin Berlin, Berlin, Germany.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Neutralizing Neurotoxic miRNA to protect the brain from neurodegenerative diseases, multiple sclerosis and stroke: MiRNA-378 prevents neurotoxicity via down regulation of its target gene. This study suggests that miRNA-378, by down regulating its target gene, it could neutralize neurotoxicity. Together, this study suggests that pharmacological formulations containing “miRNA-378 or miRNA-378 activating small molecules” can be used to neutralize neurotoxicity.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Neutralizing Neurotoxic miRNA to protect the brain from neurodegenerative diseases, multiple sclerosis and stroke: MiRNA-378 prevents neurotoxicity via down regulation of its target gene, 09/July/2014, 5.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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