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Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 

From research findings to therapeutic opportunity: 

This study suggests, for the first time, that Spermidine, by increasing the expression of its target genes,  it may decrease the expression of AT1R.

Figure1. Mechanistic insights into how Spermidine functions as a longevity-promoter. Spermidine, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity
Figure 2. The chemical structure of Spermidine.

And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Spermidine or its analogues or Berberine in combination with other anti-ageing/longevity promoting compounds may be used to extend the lifespan of an individual (Figures 1-2).

Price 300[easy_payment currency=”USD”]

Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.  

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Undisclosed mechanistic information: How  does Spermidine suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $300

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


CitationBoominathan, L.,Polyamine-based Lifespan extension therapy: Spermidine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 4/March/2018, 12.17 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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