Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Preserving the function of the guardian of the genome, p53: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 29/January/20145, 23.04, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that Cirsilol, by increasing the expression of its target gene, it may inhibit the functional inactivation of p53 by somatic mutation and viral oncognes. Thereby, it may safeguard the function of the guardian of the genome, p53. Thus, pharmacological formulations encompassing “Cirsilol or its analogues” may be used to inhibit the development of human tumors.
Amount: $ 500*
Undisclosed information: How Cirsilol preserves the function of the guardian of the genome, p53
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* Research cooperation