Preserving the function of the guardian of the genome, p53: Diallyl trisulfide, a compound isolated from Garlic, inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 1/February/2015, 22.34

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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Citation: Boominathan, Preserving the function of the guardian of the genome, p53:  Diallyl trisulfide, a compound isolated from Garlic,  inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 1/February/2015, 22.34, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that Diallyl trisulfide, by increasing the expression of its target gene, it may inhibit the functional inactivation of p53 by somatic mutation and viral oncognes. Thereby, it may safeguard the function of the guardian of the genome, p53. Thus, pharmacological formulations encompassing “Diallyl trisulfide or its analogues”  may be used to inhibit the development of human tumors.

Amount: $ 500*

Undisclosed information: How ING1b preserves the function of the guardian of the genome, p53

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* Research cooperation