Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Regenerating the lost pancreatic β-cells in DM patients: Berberine, an isoquinoline derivative alkaloid isolated from medicinal herbs, increases insulin-secreting cell mass and function via down regulation of its target genes, 6/June/2015, 11.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance:
Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult β-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.
This study suggests a Natural product-based Regenerative therapy for DM. Berberine, by increasing the expression of its target gene, it may increase insulin-secreting cell mass and function. Thereby, it may increase the insulin sensitivity of cellular tissues. Thus, pharmacological formulations encompassing “Berberine or its analogues” can be used to treat DM.
Undisclosed information: How Berberine increases insulin-secreting cell mass and function.
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