A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports a natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Hibiscus extract improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10).
Significance:
This study suggests, for the first time, that Hibiscus extract, by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardimyocyte survival/regeneration. Therefore, by consuming Hibiscus extract, one may protect himself/herself from ageing-associated decline in cardiac function. Together, pharmacological formulations encompassing “Hibiscus extract or small molecules compounds isolated from hibiscus extract” may be used to improve cardiac function after myocardial infarction. Based on this interesting finding, Physicians may consider encouraging their cardiac patients to consume Hibiscus extract, to protect themselves from heart diseases.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Regenerative Stem cell therapy for Myocardial Infarction: Hibiscus extract improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 12/April/2015, 16.04, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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* Research cooperation
Undisclosed information: How Hibiscus extract increases the expression of PNUTS/PPP1R10