A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA. shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [33.116] by Prof Daley GQ, Zhu H, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative therapy for DM: Polyomavirus enhancer activator 3 (PEA3) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28.
Significance: Prof. Daley GQ‘s laboratory has shown that loss of Lin28 promotes insulin resistance and glucose intolerance. This study suggests, for the first time, that PEA3, by increasing the expression of its target gene, it may increase the expression of RNA-binding protein Lin-28 and thereby promote insulin sensitivity. Thus, pharmacological formulations encompassing “PEA3 activators” may be used to treat DM.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed information: How PEA3 increases the expression of Lin28
To cite: Boominathan, Regenerative therapy for DM: Polyomavirus enhancer activator 3 (PEA3) promotes an insulin sensitized state via up regulation of Lin28, 28/March/2015, 23.16, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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