A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Rescuing the malfunctioning cardiomyocytes in myocardial patients: E3 ubiquitin ligase RNF2 (ring finger protein 2) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)
Significance:
This study suggests, for the first time, that RNF2 (ring finger protein 2), by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardimyocyte survival/regeneration. Therefore, this study suggests that Pitavastatin/Livalo may prevent ageing-associated decline in cardiac function. Together, pharmacological formulations encompassing “RNF2 activators” may be used to improve cardiac function after myocardial infarction.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Rescuing the malfunctioning cardiomyocytes in myocardial patients: E3 ubiquitin ligase RNF2 (ring finger protein 2) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 19/April/2014, 06.09 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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* Research cooperation
Undisclosed information: How RNF2 (ring finger protein 2) increases the expression of PNUTS/PPP1R10
