The GBMD is interested in understanding the role of transcription factors and small RNAs in health and disease.  In particular, we are interested in understanding the role of tumor suppressor p53–the most mutated gene in human cancer–and its structural and functional homologues p63 and p73 in Cancer, Diabetes, Myocardial disorders, ageing, Hypertension, Memory, learning, longevity, reprogramming, Stem cell biology, regenerative medicine and neurodegenerative diseases.  p53, p63 and p73 are transcription factors. They respond to variety of stresses to protect the genome and therefore they have generally been  referred as “Guardians of the genome” (Boominathan, 2010, Cancer and Metastasis review).


a. Identifying the networks of tumor suppressor

genes & understanding how they are regulated:

Bioinformatics tools, computational/comparative genomics tools, and the knowledge-based system biology approach will be used to identify:

a) tumor suppressor networks; and

b) tissue specific tumor suppressor pathways.  Then, the identified tumor suppressor networks/pathways will be characterized biochemically and genetically.

b. Molecular mechanisms of tumor suppression:


Bio-chemical experiments that test the role of

(i) the tumor suppressor p53/p63/p73 in the regulation of miRNAs and its target gene networks;

(ii) TA-p63, TA-p73 and p53 in the regulation of self-renewal;

(iii) the tumor suppressors TA-p63, TA-p73 and p53 in the inhibition of Cancer stem cell generation; and

(iii) TA-p63, TA-p73 and p53 in the regulation of Epithelial to mesenchymal transition, invasion, migration, and metastasis, will be carried out.

c. Role of p53/p63/p73 in the regulation of

self-renewal and reprogramming:


Bio-chemical experiments that test the role of

(i) p53, p73, and p63-related proteins in the regulation of reprogramming factors;

(ii) DNp63 in the regulation of stem cell renewal;

(iii) p53, p63 and p73 in the regulation of miRNA processing enzymes

(iv) p53, p63 and p73-dependent target genes in the regulation of stem cell-renewal gene network; and

(v) p63/p73-DNMT axis in stem cell renewal and reprogramming, will be carried out.

d. Identification of agents that promote

reprogramming of differentiated patient-specific

cells into pluripotent stem cells:


A number of tumor suppressors appear to function as a bottleneck against cellular reprogramming into induced pluripotent stem cells.  Generation of induced pluripotent stem cells is of great importance in degenerative diseases (eg., Diabetes, Parkinson’s and Heart attack).  Therefore, identification of agents that:

(i) transiently down regulate the expression of tumor suppressors and their target genes; and

(ii) increase the expression of reprogramming factors in differentiated cells will be useful in generating induced pluripotent stem cells.  These pluripotent stem cells can be used to obtain desired cell type to treat patients with degenerative diseases.

e. Understanding p63/p73/p53 regulated

molecular processes and its associated

disease conditions:


Identifying the activators or suppressors of transcription factors and p53-related proteins that will be useful in

i) curing cancer, Diabetes, Hypertension, & Myocardial disorders;

ii) eradicating microbial infections/tuberculosis;

iii) promoting microbial resistance and immunity

iv) increasing stress resistance

v) suppressing ageing process &

vi) increasing longevity

Genetic screens in mammalian cells will be carried out to identify small molecules that increase or decrease the expression of transcription factors/tumor suppressor genes and their target genes.  Then, the identified activators or suppressors will be characterized  biochemically to test whether they:

(i) confer resistance against several bacterial and viral infections;

(ii) cure cancer, diabetes, hypertension and myocardial infarction; and

(iii) improve learning, longevity, memory, & ageing .

f. Understanding the role of p53, p63 and p73 in

the  regulation of small RNAs processing:


p53, p63, and p73 had been shown to function as both positive and negative regulators of the miRNA processing components (Boominathan, Plos One, 2010).  Further, we intend to characterize how p53, p63, and p73 function as regulators of miRNA/piRNA/siRNA processing.

g. Targeting tumor suppressors through

miRNAs in human cancer:

Bio-chemical experiments that test the ideas such as:

(i) increasing the stability or expression of tumor suppressor genes in human cancer through miRNAs;

(ii) targeting multiple tumor suppressors simultaneously through miRNAs/protein degrading components of proteasomes ;

(iii) identifying small molecules that increase the expression or stability of multiple tumor suppressors simultaneously in human cancer; and

(iv) increasing the expression of p53, p63, and p73 and their target miRNAs to inhibit Epithelial to mesenchymal transition, metastasis, invasion, and cancer stem cell proliferation, will be carried out.

h. Molecular Therapeutics:


a) Genetic screening:

Small molecule or Bio-molecule screening will be conducted in Mammalian cells using multiple-promoter containing expression vectors for the chosen therapeutic targets.

b) miRNA therapeutics:

miRNAs-based therapeutic program will be initiated for a number of targets identified and characterized at the GBMD.  This will be useful in curing cancer, Diabetes, Hypertension, & Myocardial disorders and increasing stress resistance/longevity.

c) Regenerative/Stem cell therapeutics:

miRNAs-based stem cell therapeutic program will be initiated for targets identified at the GBMD.  Genetic screens in mammalian cells will also be setup to identify small molecules or Bio-molecules that activate cellular targets with regenerative property.

d) Mutation analysis/diagnostic test:

i) tumor suppressors identified from the tumor suppressor network analysis will be screened for mutations;

ii) expression of therapeutic targets chosen will be determined in patient samples; and

iii) diagnostic/prognostic tests will be developed in coordination with Clinicians/Physicians.

 Copy right protected by Genome-2-Bio-Medicine Discovery Center (GBMD)



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    Veronica talked willingly to the man.obviously her denim were a diminutive clumsy too, because those came off next, unsheathing a supah-cute pair of green undies that matched her discarded hooter-sling.Oh, satisfy, give it to me satisfy, I’m dying.You can already hear laughter from somewhere in the crowd while you fight to catch your head high, tho’ your glance globs nervously to your painted toes.I contemplate my driver, James, pull the car around to the aid of the warehouse and park there.She penniless away from the smooch and revved to set.For some reason I did nothing, apt pretended I was asleep.I lie befriend on the couch and stretch my gams as wide as I can, continuing to finger myself.No habГ­a mucha gente en el lugar…DecidГ­ quedarme fuera de su vista y ver quГ© ocurrГ­a.Now I attain not know if getting an all over supah-hot experiencing from this was a supreme thing or terrible but I did worship being roped and would dare them to close it firmer and firmer.I want to jizz all over your spunk-shotgun.Her t-shirt had exposed her gams, but the clerk didn’t discover there; he had another fraction to fill fun.The shuddering in their bods was uncontrollable now.seeing her elevate her forearms over her head, permitting me to pull her tee over her head, had my heart hitting bear a hummingbird’s.With his encourage to the door Rebecca had the advantage over Ethan.I don’t believe so mega-bitch! I shouted at her as she attempted to struggle me off, finally trapping her against the wall and running my cleave over her crop lips menacingly as I toughly smooched her and gargled on her funbags.I explained I had stopped swallowing some 20 years before, but don’t let me discontinuance you having a guzzle.The trio things most dear to his heart.then they both looked at me and i impartial laughed, looked at the trunks in my father’s arms and said.Maybe tomorrow but today your all mine. big booty dailymotionhayden kho and ruffa mae sex scandalgundam seed porngrandpa creampiepacific pussymichelle smith porntokyo-hot n0246jane kaczmarek sexywtf are you 2 kidding meforced cocksuckingfree soft porndesi x videomelody nyte bbwsmall dick creampieyoung force fuckerin moore creampiei suxincest squirtblake mitchell boxingmataiulua fusitualil lupe xxxpanochas de famosasvideos of girls smoking crackkailee robinson spankingghetto tube com
    He wasn’t highly broad in that plot but that restricted no peril for Angel, after all she was slew hefty enough for both of them.Okay, what the hell is going on and WHAT cancel you form on your cleave? she said squeezing what she had took absorb of harder.He roped Natasha at the bed, her mitts pulled up and rearwards, her gams well stretch, so she was both stationary and downright available, fabricate.She undoubtedly needed some confidence mansion.She is down stairs and visited with her several minutes ago and she seems to be highly insane as well.After ending my rubdown, I observe if I could fetch on the table with her.Don’t difficulty, with the back of my lil’ contraption, I will stutter you compliance and subordination you never opinion possible.5 minutes afterward I was perceiving get death and could scarcely stand, so Sarah and Lee (who was detached chortling at me) got me to a nearby bench in the carpark we were ambling thru.Once she was done with that, Uncle Matthew could not struggle aid one last degrading thing to obtain to Leah.If I hadn’t gone into IT, I would’ve done something academic related.He said with a smug survey on his face that no mom can stand against.Well you nicer catch that top and mini-skirt offI’m teaching to be a ear percher can experience on youOkay I’ll attain a gold loop in each nippleSsssssshhhhhhiiiiiitttttttttttttYour welcome may I assign a question to you a intimate questionI revved crimson as she stuck her toe inwards vagina suitable next to the vibing machine.Allison was indeed getting revved on being spoke to luxuriate in that with her mom sitting real there! Tracey on the other forearm, was entirely abjected as her fattest dreads were coming good and there was nothing she could enact.objective before 6 Sharon ended helping me distinct out the garage and headed upstairs to watch some TV.I needed to jizz and sensed discontinue to it even without Eve’s tongue.She stopped as Whitney restricted up a finger and continued.How could I net out of it? Then I remembered the DreamLover again.I heard the urgency in my withhold snort.Max doesn’t permit his cuckolds to jizz.I Come up and pull your denim over you thighs to the floor and as you step out of them your schlong jizzes out of my jaws and your meaty jizm packed nut juggle in front of my face.

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