1. Company website release: http://genomediscovery.org/website-release/
2. Licensing opportunities: http://genomediscovery.org/licensing-opportunities/
3. p73 regulates life span and health span: http://genomediscovery.org/p73-regulates-life-and-healthspan-20january2013-8-26-am/20/January/2013
4. How stress can weaken memories: http://genomediscovery.org/gbmd-chief-scientist-dr-boominathan-identifies-a-new-biological-pathway-that-throws-light-into-how-stress-can-weaken-memories/11/January/2013
5. Why Prolonged stress or damage to the DNA compromises one’s intellect: http://genomediscovery.org/gbmd-chief-scientist-dr-boominathan-unfolds-a-biological-mechanism-that-explains-why-prolonged-stress-or-damage-to-the-dna-can-compromise-ones-intellect/ 11/January/2013
6. Why women outlive men: http://genomediscovery.org/gbmd-chief-scientist-dr-boominathan-provides-mechanistic-insight-into-why-women-outlive-men/11/January/2013
7. Therapeutic targets that activate the immune system: http://genomediscovery.org/therapeutic-targets-that-activate-the-immune-system/5/December/2012
8. A New Biological pathway that promotes longevity in humans: http://genomediscovery.org/a-new-bio-chemical-pathway-that-promotes-longevity-in-humans-13december2012/
9. Life Span Increasing Drugs increase the expression of p63 and p73: http://genomediscovery.org/life-span-increasing-drugs-increase-the-expression-of-p63p73-3january2013-9-35-am/3/January/2013
10. P63 THE FACILITATOR OF REGENERATION: http://genomediscovery.org/patent-application-published/7/November/2012
11. P53/63/73 Functions as a regulator of pain tolerance: http://genomediscovery.org/p53p63p73-functions-as-a-regulator-of-pain-tolerance/29/November/2012
12. A new biological pathway that induces cardiac regeneration: http://genomediscovery.org/gbmd-chief-scientist-dr-boominathan-identifies-a-new-biological-pathway-that-induces-cardiac-regeneration/9/December/2012
13. Most downloaded article of the year 2010-2011: http://genomediscovery.org/most-viewed-article-of-the-year-2010-2011-in-mirna-field/
15. Vitamin C promotes Healthy aging: http//genomediscovery.org/gbmd-scientist-identify-the-mechanism-through-which-vitamin-c-promotes-healthy-aging/7/December/2012
16. How stress augments ageing: http://genomediscovery.org/mechanistic-insight-into-how-stress-augments-ageing-11january2013-12-30-am/11/January/2013
17. DeltaNp63 functions as an injury-induced proregenerative factor: http ://genomediscovery.org/injury-induces-deltanp63-dependent-regenerative-neurogenesis-27december2012 27/December/2012
18. p63 Regulates Caloric Restriction:http//genomediscovery.org/p63-regulates-caloric-restriction/12/December/2012
19. p63/p73 the Promoter of Longevity: http://genomediscovery.org/p63p73-the-facilitator-of longevity/12/December/2012 12/December/2012
20. Cellular targets that activate the immune system identifiedhttp://genomediscovery.org/therapeutic-targets-that-activate-the-immune-system-identified-by-the-chief-scientist-of-gbmd-dr-l-boominathan/5/December/2012
21. p53/p63/p73 functions as a Sentinel of Autoimmune Inflammationhttp://genomediscovery.org/p53p63p73-functions-as-a-sentinel-of-autoimmune-inflammation/29/November/2012
22. p63 the Guardian of Human Heart :http//genomediscovery.org/p63-functions-as-a-guardian-of-the-human-heart/25/November/2012
23. Proof of Principle/Concept/Success of GBMD:http//genomediscovery.org/proof-of-principleconceptsuccess-of-gbmd/
24. The GBMD has published more than 250 ideas: http://genomediscovery.org/the-gbmd-has-published-more-than-100-ideas/
25. A small molecule can mimic the effect of caloric restriction: http://genomediscovery.org/a-naturally-available-small-molecule-can-mimick-the-effect-of-caloric-restriction-29january2013-23-39/29/January/2013
26. The GBMD has published more than 300 ideas: http://genomediscovery.org/the-gbmd-has-published-more-than-100-ideas/30/January/2013
27. p63/p73 senses temperature, pain and itching: http://genomediscovery.org/gbmd-chief-scientist-dr-boominathan-unfolds-a-mechanism-through-which-p6373-senses-pain-itching-and-temperature/30/January/2013
28. GBMD Chief-Scientist Dr Boominathan has published more than 400 bio-medical Ideas: http://genomediscovery.org/the-gbmd-has-published-more-than-350-bio-medical-ideas-for-scientists/ 13/March/2013
29. GBMD Chief-Scientist Dr Boominathan reports that p63-mediates the effects of Exercise through its target gene: http://genomediscovery.org/p63-mediates-effects-of-exercise-through-its-target-gene-10march2013-14-08/
30. GBMD Chief-Scientist Dr Boominathan reports that p63/p73/p73 regulates taste perception: http://genomediscovery.org/p63p73p73-regulates-taste-perception-13march2013-7-33-am/
31. GBMD Chief-Scientist Dr Boominathan Ph.D. reports that p53/p63/p73 plays a significant role in deciding whether to cleave or to promote translational repression of miRNA targets. This study may aid in the treatment of miRNA-dependent disorders. http://genomediscovery.org/to-cleave-or-not-to-cleave-p53p63p73-promotes-cleavage-and-down-regulates-repression-of-mirna-targets-29april2013-8-55-am/ 29/April/2013
32. GBMD Chief-Scientist Dr Boominathan Ph.D. reports that p53/p63/p73 may increase longevity by targeting a component in the inflammatory pathway. p53/p63/p73 may increase longevity by about 20%. This study may (i) throw light into how “p63/p73/p53 activators” could aid in increasing longevity of organisms ; and (2) aid in the treatment of ageing disorders, including cognitive decline.http://genomediscovery.org/p63p73p53-increases-longevity-by-targeting-a-component-in-the-inflammatory-pathway-2april2013-22-07/3/May/2013
33. Dr Boominathan had shown earlier that TAp73 stabilizes the protooncogene c-Jun, but the mechanism remained elusive (http://scholarbank.nus.edu.sg/handle/10635/15006 ). Nearly after a decade, GBMD Chief-Scientist Dr Boominathan Ph.D. identifies the mechanism through which TAp73 stabilizes c-Jun. His results reveal that p73 increases the stability of Jun by turning on its target miRNA. This, in turn, suppresses the expression of a protein that targets c-Jun for degradation. http://genomediscovery.org/ta-p73-stabilizes-c-jun-by-turning-on-its-target-mirna-6may2013/
34. It has earlier been shown that Vitamin-C induces the expression of p73. Further, it has recently been shown that Vitamin C cures Tuberculosis. Here, GBMD Chief-Scientist Dr Boominathan Ph.D. identifies the mechanism through which Vitamin C inhibits Tuberculosis. His results reveal that Vitamin-C induced p73 inhibits Tuberculosis. This study may aid in the treatment of tuberculosis. http://genomediscovery.org/vitamin-c-p73-pathway-may-cure-tuberculosis-27may2013-22-03/
35. GBMD Chief-Scientist Dr Boominathan PhD reports that activation of p53/p63/p73-dependent biological pathway may inhibit HIV entry. Furthermore, Dr Boominathan identifies mechanism through which p53/p63/p73 inhibits HIV entry. This study suggests that “p63/p73/p53 activators” may find its use in inhibiting HIV entry. http://genomediscovery.org/activation-of-p53p63p73-inhibits-hiv-entry-27may2013-21-47/
36. Teacher’s day special: We are happy to announce that ideas posted today (5/September/2013) will be available to the use of Scientists/Professors/Teachers for free. So, there are no terms and conditions will apply. Each idea will be served first come, first served basis to three to five research teams.Write to Drboomi@genomediscovery.org for more details. (5/September/2013)
37. GBMD Chief-Scientist Dr Boominathan PhD provides molecular insight into pathogenic mechanisms of Non-Obstructive Azoospermia. In particular, Dr Boominathan identifies the mechanism through which p53 regulates Spermatogenesis and Sertoli Cell Polarity via up regulation of its target gene. This study suggests that “p53 regulators” may find its use in clinic treating stress-induced Azoospermia. To the best of our knowledge, this is the first study that points out a role for the guardian of the genome p53 in stress-induced Azoospermia. http://genomediscovery.org/insights-into-non-obstructive-azoospermia-p53-regulates-spermatogenesis-and-sertoli-cell-polarity-via-up-regulation-of-its-target-gene-12september2013-9-15-am/
38. GBMD Chief-Scientist Dr Boominathan PhD reports that p63 regulates homeostatic and regenerative hematopoiesis via up regulation of its target gene. Furthermore, Dr Boominathan identifies mechanism through which p63 controls hematopoietic regeneration. This study suggests that “p63 activators” may find its use in regeneration of hematopoietic cells. http://genomediscovery.org/hematopoietic-regeneration-p63-regulates-homeostatic-and-regenerative-hematopoiesis-via-up-regulation-of-its-target-gene-13september2013-8-19-am/
39. GBMD Director-cum-Chief-Scientist Dr L Boominathan PhD reports that miR-100 may increase the life span of an individual. Furthermore, Dr Boominathan identifies the mechanism through which miR-100 increases the life span of an individual. This study suggests that “miR-100 activators” may increase one’s longevity.
The average life span of an individual in certain parts of the world varies from 80 to 85 years. Dr Boominathan envisions that miR-100 activators may increase the life span of an individual by 20%. If this supposition turns out to be true, then the average life span of an individual may increase from 80 to 100 years.
Thus, Dr L Boominathan believes that miR-100 functions as the “longevity promoter.” http://genomediscovery.org/mir-100-can-increase-the-life-span-of-an-individual-to-100-years-mir-100-increases-life-span-of-an-individual-by-suppressing-its-target-gene-17september2013-9-46-am/
40. GBMD Director-cum-Chief-Scientist Dr L Boominathan PhD reports that p73 promotes cardiac regeneration and improves contractility after myocardial infarction. Furthermore, Dr Boominathan identifies the mechanism through which p73 promotes cardiac regeneration. This study suggests that “p73 pathway regulators” may increase cardiac regeneration after myocardial infarction. http://genomediscovery.org/p73-promotes-cardiac-regeneration-and-improves-contractility-after-myocardial-infarction-24september2013-19-09/
41. The Nobel Prize Winner in Physiology or Medicine (2012), Gurdon JB from Wellcome Trust/Cancer Research Gurdon Institute, Cambridge, UK reports in the prestigious journal Science that Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development. Based on this remarkable finding Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that the tumor suppressor gene p53/p63/p73 regulates the expression of Wave1 through its target genes. Furthermore, Dr Boominathan identifies the mechanism through which p53 and its homologues p63 and p73 regulate the maternal reprogramming factor Wave1. This exciting finding explains how stress induced p53 may cause abnormal development. Therefore, Dr Boominathan posits that this finding has great clinical utility.http://genomediscovery.org/the-tumor-suppressor-gene-p53p63p73-regulates-the-expression-of-wave1-through-its-target-genes-24september2013-20-42/
42. GBMD Director-cum-Chief-Scientist Dr L Boominathan PhD reports that MiR-20 improves insulin sensitivity and ameliorates diabetes. Furthermore, Dr Boominathan identifies the mechanism through which miR-20 improves insulin sensitivity. This study suggests that “miR-20 activators” may improve insulin sensitivity and ameliorate diabetes. http://genomediscovery.org/mir-20-improves-insulin-sensitivity-and-ameliorates-diabetes-26september2013-5-47-am/
43. More to our Proof of Principle/Concept/Success: The GBMD’s Chief-Scientist Dr Boominathan had proposed on March 23, 2013 (and in a number of other dates in 2012 and 2013-http://genomediscovery.org/molecular-insights-into-pain-mechanism-p53p63p73-regulates-pain-perception-via-targeting-sodium-channel-voltage-gated-type-xi-%CE%B1-subunit-14november2013-5-41-am/; http://genomediscovery.org/insights-into-pain-mechanism-tumor-suppressor-p53-increases-cox-2-expression-and-prostaglandin-e2-pge2-production/; http://genomediscovery.org/hyperalgesia-p53p63p73-controls-the-severity-and-duration-of-inflammatory-pain-responses-5november2013-6-38-am/; http://genomediscovery.org/molecular-insights-into-pain-mechanism-p53-suppresses-mechanical-hyperalgesia-in-mice-via-induction-of-its-target-mirna-30september2013-7-10-am/; http://genomediscovery.org/assigning-new-function-to-an-old-pain-reliever-diclofenac-activates-a-number-of-tumor-suppressor-mirnas-by-repressing-its-target-gene-2august2013-10-41-am/ http://genomediscovery.org/assigning-new-function-to-an-old-pain-reliever-diclofenac-activates-a-number-of-tumor-suppressor-mirnas-by-repressing-its-target-gene-2august2013-10-41-am/; http://genomediscovery.org/p53p63p73-functions-as-regulators-of-pain-tolerance-6july2012/; http://genomediscovery.org/p63p73-senses-temperature-pain-and-itching-30january2013/) that p63/p73 regulates thermal and neuropathic pain [http://genomediscovery.org/p63p73-regulates-thermal-and-neuropathic-pain-23march2013-21-56/]. Evidently, on Nov 4, 2013, Niklison-Chirou MV and Melino G (from Toxicology Unit, Medical Research Council, Leicester, United Kingdom) have published a paper in the high profile journal PNAS stating that “p73 null mice also have impairments in the peripheral nervous system with reduced thermal sensitivity, axon number, and myelin thickness” (http://www.ncbi.nlm.nih.gov/pubmed/24190996). It is important to understand that this research paper was published nearly eight months (Nov 4, 2013) later from the date of publication made by Dr L Boominathan. This serves as a strong supporting evidence for the fact that our scientific minds and ideas matches with the best in the world. Refer this link for our earlier success: http://genomediscovery.org/proof-of-principleconceptsuccess-of-gbmd/ (14november2013-5-41-am)
44. Extending life span and delaying aging: p63-mediated activation of NK2x2 and Ox2r results in increased life span and decreased ageing, 5/October/2013, 22.32 GBMD Director-cum-Chief-Scientist Dr L Boominathan PhD reports that p63-mediated activation of NK2x2 and Ox2r results in increased life span and decreased ageing. Furthermore, Dr Boominathan identifies the mechanism through which p63 increases life span and decreases ageing. Together, this study suggests that “p63 pathway regulators” may delay ageing and extend the life span of an individual. Therefore, Dr L Boominathan strongly believes that p63 acts as the ”Protector of ageing and the Extender of Life span“ To cite: Boominathan,Extending life span and delaying aging: p63-mediated activation of NK2x2 and Ox2r results in increased life span and decreased ageing, 5/October/2013, 22.32, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
45. A number of studies suggest that the mTOR inhibitor Sirolimus extends life span. However, how Sirolimus increases longevity remains unclear. Identifying the mechanism by which Sirolimus extends life span is of paramount importance in longevity research. Here, GBMD Founder Director-cum-Chief-Scientist Dr L Boominathan PhD reports that Sirolimus extends lifespan by inducing the expression of Autophagy-related gene ATG5. Furthermore, Dr Boominathan identifies the molecular mechanism through which Sirolimus extends life span. To cite: Boominathan, Mechanistic insights into how Sirolimus promotes Longevity: Sirolimus activates autophagy and extends lifespan by inducing the expression of Autophagy-related gene ATG5, 19/November/2013, 6.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
46. Noble Laureate Prof. David Baltimore (USA) has reported in the Journal Immunology ( J Immunol. 2011 Nov 15;187(10):5062-8) that miRNAs play a significant role in stimulating Mф/Immune cell activation. In connection with this study, here, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports that ATRA (Vitamin A) decreases IFN regulatory factor 4 (IRF4) expression via up regulation of its target gene. Thereby, ATRA (Vitamin A) augments Mф/Immune cell activation. Together, this study suggests that Vitamin-A can be used to augment immune cell activation. To cite: Boominathan, L, Vitamin-mediated Mф/Immune cell activation: ATRA (Vitamin A) decreases IFN regulatory factor 4 (IRF4) expression via up regulation of its target gene, 7/December/2013, 5.49 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
47. The Follow-up of Noble laureates’s (Shinya Yamanaka) favorite work: LIN-41/TRIM71 suppresses the expression of p53 homologue p73 via down regulation of its target gene, 14/December/2013, 8.31 am. Noble Laureate Prof. Shinya Yamanaka (from San Francisco, USA; Japan) has reported in the journal Cell Stem Cell that “The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes.“ As a follow-up of this study, here, Dr Boominathan, Chief-Scientist-cum-Director of GBMD, reports that LIN-41/TRIM71 suppresses the expression of p53 homologue p73 via down regulation of its target gene, 14/December/2013, 8.31 am. To cite: Boominathan, The Follow-up of Noble laureates’s (Shinya Yamanaka) favorite work: LIN-41/TRIM71 suppresses the expression of p53 homologue p73 via down regulation of its target gene, 14/December/2013, 8.31 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
48. Noble Laureate Prof. Shinya Yamanaka (from San Francisco, USA) has reported in the journal Cell Stem Cell that “The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes.“ As a follow-up of this study, here, Dr Boominathan, Chief-Scientist-cum-Director of GBMD, reports that Let-7 miRNA increases the expression of tumor suppressor p53 homologue p73 via down regulation of its target gene, 14/December/2013, 8.44 am. To cite: Boominathan, The Follow-up of Noble laureates’s (Shinya Yamanaka) favorite work: Let-7 miRNA increases the expression of tumor suppressor p53 homologue p73 via down regulation of its target gene, 14/December/2013, 8.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
49. Noble Laureate Prof. Phil Sharp (from MIT, Cambridge, USA) has published a paper in the Journal Genes & Development stating that Let-7 represses Nr6a1 and a mid-gestation developmental program in adult cells. This study suggests that “let-7 is required for the continual suppression of embryonic gene expression in adult cells.“ In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Insights into the regulation of a mid-gestation developmental program: 1,25-Dihydroxyvitamin D3 suppresses Nr6a1 and embryonic gene expression programs in adult cells. This study may through light into the tumor suppressive action of 1,25-Dihydroxyvitamin D3. To cite: Boominathan, Insights into the regulation of a mid-gestation developmental program: 1,25-Dihydroxyvitamin D3 suppresses Nr6a1 and embryonic gene expression programs in adult cells, 24/December/2013, 7.24 am,Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
50. Noble Laureate Prof. Phil Sharp (from MIT, Cambridge, USA) has published a paper in the Journal Genes & Development stating that Let-7 represses Nr6a1 and a mid-gestation developmental program in adult cells. This study suggests that “let-7 is required for the continual suppression of embryonic gene expression in adult cells.“ In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Insights into the regulation of a mid-gestation developmental program: Androgens decrease Nr6a1 and embryonic gene expression programs in adult cells. This study may through light into the tumor suppressive action of androgens. To cite: Boominathan, Insights into the regulation of a mid-gestation developmental program: Androgens decrease Nr6a1 and embryonic gene expression programs in adult cells, 24/December/2013, 7.35 am,Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
51. Noble Laureate Prof. Phil Sharp (from MIT, Cambridge, USA) has published a paper in the Journal Genes & Development stating that Let-7 represses Nr6a1 and a mid-gestation developmental program in adult cells. This study suggests that “let-7 is required for the continual suppression of embryonic gene expression in adult cells.“ In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Insights into the regulation of a mid-gestation developmental program: Estrogens (E2) decrease Nr6a1 and embryonic gene expression programs in adult cells. This study may through light into the tumor suppressive action of Estrogens. To cite: Boominathan, Insights into the regulation of a mid-gestation developmental program: Estrogens decrease Nr6a1 and embryonic gene expression programs in adult cells, 24/December/2013, 8/56 am,Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
52. Prof. David J Adams (from Experimental Cancer Genetics, Sanger Institute, Hinxton, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) has published a paper in the Journal Nature genetics stating that “Inactivating Cux1 mutations promote tumorigenesis.“ This study suggests that: 1) CUX1 mutations promote tumorigenesis; 2) CUX1 is mutated in ~1–5% of various tumors; and 3) CUX1 deficiency activates the phosphoinositide 3-kinase (PI3K) pathway. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Tumorigenesis: Oct-4 and Sox2 suppress the expression of a new tumor suppressor gene CUX1 via induction of their target gene, 26/December/2013, 4.28 am. This study may explain how oncogenic/reprogramming factors such as Oct-4 and Sox2 can transform cells by suppressing the expression of Cux1.
53. Prof. David J Adams (from Experimental Cancer Genetics, Sanger Institute, Hinxton, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) has published a paper in the Journal Nature genetics stating that “Inactivating Cux1 mutations promote tumorigenesis.” This study suggests that: 1) CUX1 mutations promote tumorigenesis; 2) CUX1 is mutated in ~1–5% of various tumors; and 3) CUX1 deficiency activates the phosphoinositide 3-kinase (PI3K) pathway. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Tumorsuppression: p53, p63 and p73 regulate the expression of a new tumor suppressor gene CUX1 via induction of their target gene, 26/December/2013, 4.33 am. This study may through light into a new tumor suppressor pathway involving p53 and its homologues p63 and p73 and Cux1.
54. Noble Laureate Prof. Phil Sharp (from MIT, Cambridge, USA) has published a paper in the Journal Genes & Development stating that Let-7 represses Nr6a1 and a mid-gestation developmental program in adult cells. This study suggests that “let-7 is required for the continual suppression of embryonic gene expression in adult cells.“ In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Insights into the regulation of a mid-gestation developmental program: Metformin decreases Nr6a1 and embryonic gene expression programs in adult cells. This study may through light into the tumor suppressive action of Metformin. To cite: Boominathan, Insights into the regulation of a mid-gestation developmental program: Metformin decreases Nr6a1 and embryonic gene expression programs in adult cells, 29/December/2013, 7.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
55. It is known for years that prolonged alcohol consumption impairs memory and learning. However, molecular basis of which remains unknown. Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Prolonged ethanol consumption impairs the expression of Brain-derived Neurotrophic factor [BDNF] via up regulation of its target miRNA. Thereby, it impairs learning and memory. This study may aid in designing strategy to treat and cure the learning and memory deficit caused by prolonged alcohol consumption. To cite: Boominathan, Mechanistic insight into why alcohol impairs your learning and memory: Prolonged ethanol consumption impairs the expression of Brain-derived Neurotrophic factor [BDNF] via up regulation of its target miRNA, 30/December/2013, 8.39 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
56. GBMD’s Ideas were Viewed by World’s best 10 institutions/universities: We are happy to announce that some of the Ideas posted by the Genome-2-Bio-Medicine Discovery center (GBMD) were viewed by the premier institutions, including the best 10 universities/institutions, in the World: http://genomediscovery.org/ideas/ideas-viewed-by-worlds-best-10-institutions/-Dr L Boominathan, PhD., Chief Scientist-cum-Director, GBMD; 31/December/2013.
57. Dr Charles J Holahan from the University of Texas at Austin (USA) has published a paper in the Journal Alcoholism: Clinical and Experimental Research stating that moderate drinking prolongs the life span of individuals. In relation to this study, some of the catchy sentences that were published by the News papers include “Why do heavy drinkers outlive Nondrinkers?”; “People who drink alcohol outlive those who abstain“; “Heavy drinkers outlive Non-drinkers: Cheers to that“; and “A sobering truth, drinkers live longer than non-drinkers.” However, molecular basis of this finding largely remains unknown.
Here, Dr L Boominathan, Director-cum-chief scientist of GBMD, seems to have found answer for the question: How/why does alcohol help one live longer? Dr L Boominathan further reports here that “the issue of Morality versus Mortality: Molecular mechanistic insight into why moderate drinking prolongs life span of individuals.” Given the scientific justification (molecular basis) that encourages moderate drinking, our study may through light into the positive effects of moderate alcohol consumption in prolonging the life span of an individual. To cite: Boominathan, The issue of Morality versus Mortality: Molecular mechanistic insight into why moderate drinking prolongs life span of individuals, 1/January/2014, 9.17 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org; Courtesy: When you cite drop us a line at info@genomediscovery.org
Attention: “This article in not intended to suggest that drinking alcohol is good for you, or suggest that you start drinking. There are many factors in a persons life to be considered, and the best way to get the right answers would be to consult with the family doctor”(Graham, Digital Journal, 2014) or wait till we have complete mechanistic understanding of the effect of alcohol.
58. Boominathan, Molecular therapy for Cancer: Black pepper increases the expression of tumor suppressor and the “guardian of the genome” p53 via down regulation of its target gene, 4/January/2013, 7.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
59. Boominathan, Molecular therapy for Cancer: Turmeric increases the expression of tumor suppressor and the “guardian of the genome” p53 via down regulation of its target gene, 4/January/2013, 7.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
60. Boominathan, Molecular therapy for Cancer: Myristica fragrans Houtt. (nutmeg) increases the expression of tumor suppressor and the “guardian of the genome” p53 via down regulation of its target gene, 4/January/2013, 7.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
61. Boominathan, Insights into why exercise is a good stress reliever: Endurance exercise suppresses the expression of stress responder and the tumor suppressor p53 in skeletal muscle, 4/January/2014, 9.24 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
62. Boominathan, Moderate drinking lowers Insulin resistance: Ethanol restores liver insulin responsiveness via down regulation of its target gene, 10/January/2014, 7.29 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
63. Boominathan, Molecular mechanistic insight into how moderate drinking of alcohol lowers Insulin resistance: Ethanol increases the expression of insulin receptor substrate 2 (IRS2) via down regulation of its target gene, 10/January/2014, 7.45 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
64. Boominathan, Insights into the regulation of innate antiviral response: Tumor suppressor p53 homologue TAp63 increases the expression of interferon-induced protein MxA via up regulation of its target gene, 12/January/2014, 6.17 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
65. Boominathan, Therapeutic insights into fragile X syndrome: Metformin improves learning and rescues neurogenesis via up regulation of its target gene, 13/January/2014, 8.36 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
66. Boominathan,Cautions against consumption of fungicide-treated fruits and vegetables:The antifungal agent Fenhexamid, which is present at measurable amounts in fruits and vegetables, suppresses the expression of tumor suppressor PTEN via up regulation of its target gene, 13/January/2014, 8.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
67. Boominathan, Longevity: Aspirin extends the life span of individuals via induction of Sirtuins, 15/January/2014, 5.55 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
68. Boominathan, Molecular therapy for Diabetic nephrophathy: Curcumin, the major component of food flavour turmeric, inhibits progressive renal inflammation, fibrosis and diabetic nephrophathy via induction of its target gene, 23/January/2014, 7.23 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
69. Boominathan, Molecular therapy for Diabetic nephrophathy: Ginseng inhibits progressive renal inflammation, fibrosis, & diabetic nephrophathy via induction of its target gene, 23/January/2014, 7.45 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
70. The Nobel Prize Winner in Physiology/Medicine (1975), Prof. David Baltimore from California Institute of Technology (Caltec), California, USA, has reported in a number of prestigious journals that NFKB regulates the expression of a number of miRNAs. In connection with Nobel Laureate Baltimore’s findings, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that NFKB suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene. To cite: Boominathan, NFKB suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene, 6/February/2014, 12.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
71. The Nobel Prize Winner in Physiology/Medicine (1975), Prof. David Baltimore from California Institute of Technology (Caltec), California, USA, has reported in a number of prestigious journals that NFKB regulates the expression of miR-146. In connection with Nobel Laureate Baltimore’s findings, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that BRMS1 (Breast cancer metastasis suppressor 1) suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene. To cite: Boominathan, BRMS1 (Breast cancer metastasis suppressor 1) suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene, 6/February/2014, 12.39 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
72. The Nobel Prize Winner in Physiology/Medicine (1975), Prof. David Baltimore from California Institute of Technology (Caltec), California, USA, has reported in a number of prestigious journals that NFKB regulates the expression of a number of miRNAs. In connection with Nobel Laureate Baltimore’s findings, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that Celastrol, an antioxidant and anti-inflammatory drug, suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene. To cite: Boominathan, Molecular cancer therapy: Celastrol, an antioxidant and anti-inflammatory drug, suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene, 7/February/2014, 22.13, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
73. Prof. Dr Kouzarides and the Nobel Prize Winner in Physiology/Medicine (2012) Prof Dr Gurdon JB from Cancer Research Gurdon Institute, Cambridge, UK reports in the prestigious journal Nature (2014) that “Citrullination regulates pluripotency….” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Dismantling stem cell network: Tumor suppressor p53 inhibits the embryonic stem cell transcriptional network through induction of its target gene peptidylarginine deiminase-4. Furthermore, Dr Boominathan identifies the mechanism by which p53 and its homologues p63 and p73 regulate citrullination of arginine residues in proteins. This exciting finding explains how stress induced p53 and its homologues TA-p63 and TA-p73 inhibit the pluripotency transcriptional network in normal cells and in cancer cells. To cite: Boominathan, Dismantling stem cell network: Tumor suppressor p53 inhibits the embryonic stem cell transcriptional network through induction of its target gene peptidylarginine deiminase-4, 10/February/2014, 8.34 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
74. Boominathan, Insights into cartilage development & the height determining mechanism: Genistein increases the expression of Integral membrane protein 2a [ITM2A] via down regulation of its target gene, 10/February/2014, 9.49 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
75. Boominathan, Insights into how a small RNA can increase your height: An miRNA suppresses the expression of Integral membrane protein 2a [ITM2A] via down regulation of its target gene, 12/February/2014, 8.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
76. Noble Laureate in Medicine (1998) Prof. Dr Feirid (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor TPM1 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor TPM1 via up regulation of its target gene, 15/February/2014, 14.35, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
77. Noble Laureate in Medicine (1998) Prof. Dr Feirid (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor KRIT1/CCM1 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor KRIT1/CCM1 via up regulation of its target gene, 15/February/2014, 14.40, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
78. Noble Laureate in Medicine (1998) Prof. Dr Feirid (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor TIMP3 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of tumor suppressor TIMP3 via up regulation of its target gene, 16/February/2014, 7.18 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
79. Noble Laureate in Medicine (1998) Prof. Dr Feirid (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor PDCD4 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of tumor suppressor PDCD4 via up regulation of its target gene, 17/February/2014, 8.54 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
80. Prof. Helen M Blau (from Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA) has published a research paper in the prestigious Journal Nature Medicine (Feb, 2014) stating that “Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.” This study suggests that transient inhibition of p38α and p38β strengthens muscles of aged mice. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular mechanistic insights into how Androgens function as Muscle strengtheners: Androgens restore the strength of injured aged muscles by rejuvenating muscle stem cell population. This finding further suggests that androgens increase muscle stem cell population via up regulation of their target miRNA. Furthermore, this exciting finding opens up a new therapeutic opportunity to help elderly human patients to repair muscle damage. To cite: Boominathan, Molecular mechanistic insights into how Androgens function as Muscle strengtheners: Androgens restore the strength of injured aged muscles by rejuvenating muscle stem cell population, 18/February/2014, 10.24 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
81. Boominathan, Therapeutic insights into the treatment of Muscle wasting: 1,25-dihydroxyvitamin D restores strength of injured aged muscles via up regulation of its target gene, 18/February/2014, 8.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
82. Boominathan, Molecular insight into the side effects of anti-cancer drug treatment: The anti-cancer drug Campothecin (CPT) promotes progressive muscle weakness via down regulation of its target gene, 18/February/2014, 9.12 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
83. Boominathan, Therapeutic insights into the treatment of Muscle wasting: Valproic acid, an anticonvulsant drug, restores strength of injured aged muscles, 18/February/2014, 10.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
84. Noble Laureate in Medicine (1998) Prof. Dr Feirid (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor GRHL3 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of tumor suppressor GRHL3 via up regulation of its target gene, 18/February/2014, 10.49 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
85. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of DNA repair protein hMSH2 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of DNA repair protein hMSH2 via up regulation of its target gene, 19/February/2014, 10.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
86. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor p53 homologue TAp63 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of tumor suppressor p53 homologue TAp63 via up regulation of its target gene, 20/February/2014, 7.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
87. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of pro-apoptotic protein BTG2 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of pro-apoptotic protein BTG2 via up regulation of its target gene, 22/February/2014, 22.13, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
88. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of pro-apoptotic protein Fas Ligand (FasL) via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of pro-apoptotic protein Fas Ligand (FasL) via up regulation of its target gene, 24/February/2014, 10.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
89. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor lncRNA GAS5 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of tumor suppressor lncRNA GAS5 via up regulation of its target gene, 27/February/2014, 8.56 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
90. National Science day special: We wish every one a very happy National Science day. On this special occasion, we are happy to announce that ideas posted today (28/February/2014) will be available to the use of Scientists/Professors/Physicians/Researchers for free. So, there will be no terms and conditions for the ideas posted today (28/February/2014). Each idea posted will be served first come, first served basis.Write to info@genomediscovery.org for more details about the ideas posted.-Dr L Boominathan PhD, Director, GBMD.
Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor RECK via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy. To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of RECK tumor suppressor via up regulation of its target gene, 28/February/2014, 9.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
91. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Molecular insights into Cancer therapy: NOS-2 suppresses the expression of tumor suppressor TNFAIP8L2 via up regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may improve caner therapy.To cite: Boominathan, Insights into Molecular cancer therapy: NOS-2 suppresses the expression of tumor suppressor TNFAIP8L2 via up regulation of its target gene, 3/March/2014, 8.50 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
92. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Mechanistic insights into Cancer therapy: NOS-2 increases the levels of cell cycle protein Cyclin D1 via up regulation of its target gene. This study provides mechanistic insights into why increased expression of NOS-2 promotes tumorigenesis, while inhibition of its expression improves caner therapy. To cite: Boominathan, Mechanistic insights into Cancer therapy: NOS-2 increases the levels of cell cycle protein Cyclin D1 via up regulation of its target gene, 11/March/2014, 13.47, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
93. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Treating cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses the expression of NOS2 via up regulation of its target gene. This study provides mechanistic insights into how Celastrol inhibits the expression of NOS-2. To cite: Boominathan, Treating cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses the expression of NOS2 via up regulation of its target gene, 13/March/2014, 11.45, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
94. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Treating cancer with longevity promoting drugs: Resveratrol, a longevity promoting small molecule, suppresses the expression of NOS2 via up regulation of its target gene. This study provides mechanistic insights into how Resveratrol inhibits the expression of NOS-2To cite: Boominathan, Treating cancer with longevity promoting drugs: Resveratrol, a longevity promoting small molecule, suppresses the expression of NOS2 via up regulation of its target gene, 13/March/2014, 11.55, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
95. Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, increases the expression of tumor suppressor p16(Ink4a) via down regulation of its target gene. This study provides mechanistic insights into how inhibition of NOS-2 may aid cancer therapy. To cite: Boominathan, Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, increases the expression of tumor suppressor p16(Ink4a) via down regulation of its target gene, 14/March/2014, 23.42, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org.
96. Prof. Dr Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA report in the prestigious journal Cell (2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Cell-density-dependent Regulation of miRNA biogenesis: Breast cancer metastasis suppressor LIFR promotes wide spread miRNA biogenesis via down regulation of its target gene. To cite: Boominathan, Cell-density-dependent Regulation of miRNA biogenesis: Breast cancer metastasis suppressor LIFR promotes wide spread miRNA biogenesis via down regulation of its target gene, 8/March/2014, 22.30, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
97. Prof. Dr Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA report in the prestigious journal Cell (2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into Cell-density-dependent miRNA Biogenesis: miR-375 promotes wide-spread miRNA biogenesis via down regulation of its target gene. To cite: Boominathan, Insights into Cell-density-dependent miRNA Biogenesis: miR-375 promotes wide-spread miRNA biogenesis via down regulation of its target gene, 10/March/2014, 9.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
98. Prof. Dr Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA report in the prestigious journal Cell (2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into Cell-density-dependent miRNA Biogenesis: The Merlin/NF2 tumor suppressor promotes wide-spread miRNA biogenesis via down regulation of its target gene. To cite: Boominathan, Insights into Cell-density-dependent miRNA Biogenesis: The Merlin/NF2 tumor suppressor promotes wide-spread miRNA biogenesis via down regulation of its target gene, 12/March/2014, 21.29 , Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
99. Prof. Dr Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA report in the prestigious journal Cell (2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into Cell-density-dependent miRNA Biogenesis: Menin1 suppresses wide spread miRNA processing via up regulation of its target gene. To cite: Boominathan, Insights into Cell-density-dependent miRNA Biogenesis: Menin1 suppresses wide spread miRNA processing via up regulation of its target gene, 13/March/2014, 8.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
100. Prof. Dr Kouzarides and his co-workers from Cancer Research Gurdon Institute, University of Cambridge, UK report in the prestigious journal Molecular Cell (2014) that “The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into tumor hypoxia: The Breast Cancer Oncogene EMSY increases the expression of FIH (Factor inhibiting Hypoxia inducible Factor) via down regulation of its target gene. To cite: Boominathan, Insights into tumor hypoxia: The Breast Cancer Oncogene EMSY increases the expression of FIH (Factor inhibiting Hypoxia inducible Factor) via down regulation of its target gene, 8/March/2014, 21.48, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
101. Prof. Dr Kouzarides and his co-workers from Cancer Research Gurdon Institute, University of Cambridge, UK report in the prestigious journal Molecular Cell (2014) that “The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into the targeting of cancer progression: The Breast Cancer Oncogene EMSY increases the expression of SATB2 via down regulation of its target gene. To cite: Boominathan, Insights into the targeting of cancer progression: The Breast Cancer Oncogene EMSY increases the expression of SATB2 via down regulation of its target gene, 8/March/2014, 22.02, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
102. Prof. Dr Kouzarides and his co-workers from Cancer Research Gurdon Institute, University of Cambridge, UK report in the prestigious journal Molecular Cell (2014) that “The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into the regulation of RAS signaling pathway: The Breast Cancer Oncogene EMSY increases the expression of RASA1 via down regulation of its target gene. To cite: Boominathan, Insights into the targeting of cancer progression: Insights into the regulation of RAS signaling pathway: The Breast Cancer Oncogene EMSY increases the expression of RASA1 via down regulation of its target gene, 10/March/2014, 8.17 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
103. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Treating Psoriasis with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from Thunder of God vine, ameliorates the disease pathology of Psoriasis by down regulating its target gene, 4/March/2014, 7.07 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
104. The Nobel Prize Winner in Physiology/Medicine (1975), Prof. David Baltimore from California Institute of Technology (Caltec), California, USA, has reported in a number of prestigious journals that NFKB regulates the expression of a number of miRNAs. In connection with Nobel Laureate Baltimore’s findings, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that Celastrol, an antioxidant and anti-inflammatory drug, suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene. To cite: Boominathan, Molecular cancer therapy: Celastrol, an antioxidant and anti-inflammatory drug, suppresses the expression of epigenetic integrator UHRF1 via up regulation of its target gene, 7/February/2014, 22.13, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
105. Dr Boominathan, Director-cum-Chief Scientist of GBMD, reports for the first time that Centipede grass extract suppresses the expression of a bio-marker of ageing p16INK4a, 13/March/2014, 22.55. Dr L Boominathan has discovered the mechanism by which Centipede grass extract slows down ageing. Based on this exciting finding, Dr L Boominathan suggests that drinking Centipede grass may keep one younger for long. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Drink Centepede grass juice to slow down Ageing: Centipede grass extract suppresses the expression of a bio-marker of ageing p16INK4a via down regulation of its target gene, 13/March/2014, 22.55, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
106. Dr Boominathan, Director-cum-Chief Scientist of GBMD, reports for the first time that 6-gingerol, a compound derived from Ginger, increases the expression of a longevity gene telomerase (hTERT), 13/March/2014, 22.53. Dr L Boominathan has discovered the mechanism by which 6-gingerol increases the longevity. Based on this exciting finding, Dr L Boominathan suggests that drinking ginger juice may increase healthspan and longevity.
Idea Proposed/Formulated by Dr Boominathan,Ph.D.;Web:http://genomediscovery.org;
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Drink Ginger juice to increase healthspan and longevity: 6-gingerol, a compound derived from Ginger, increases the expression of a longevity gene telomerase (hTERT) via down regulation of its target gene, 14/March/2014, 23.48, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
107. Dr Boominathan, Director-cum-Chief Scientist of GBMD, reports for the first time that 6-gingerol, a compound derived from Ginger, increases the expression of a bio-marker of ageing INK4a/p16, 13/March/2014, 22.53. Dr L Boominathan has discovered the mechanism by which 6-gingerol slows down Ageing and Senescence process. Based on this exciting finding, Dr L Boominathan suggests that drinking ginger juice may decrease Ageing and Senescence process and keep one younger for long. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Take Ginger juice to slow down Ageing and Senescence process: [6]-Gingerol, a compound derived from Ginger, suppresses the expression of a bio-marker of ageing INK4a/p16 via down regulation of its target gene, 7/March/2014, 23.14, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
108. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Insights into iPS cells generation, stem cell therapy, ageing and longevity: [6]-Gingerol, a compound derived from ginger, promotes reprogramming of differentiated cells into iPS cells via down regulation of its target gene, 16/March/2014, 23.38, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
109. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Insights into age- and stress-suppressing agents: Citrus aurantium flavonoids suppress the expression of tumor suppressor/stress responder p53 via down regulation of its target gene, 17/March/2014, 23.41, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
110. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Insights into iPS cells generation and anti-cancer therapy: Olive oil oleuropein inhibits reprogramming of differentiated cells into iPS cells via up regulation of its target gene, 16/March/2014, 23.53, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
111. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Ever wondered why Indian women apply turmeric powder on their face: Curcumin, the major component of turmeric, inhibits hair follicle–stem cell [HF-SC] maintenance via up regulation of its target gene, 2/March/2014, 18.26, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
112. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Treating Psoriasis with Turmeric: The curcumin analog EF24 ameliorates the disease pathology of Psoriasis by down regulating its target gene, 3/March/2014, 6.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
113. Pop vitamin-A pills to protect yourself from heart attack: ATRA protects against myocardial ischemia/reperfusion injury via up regulation of its target gene.; Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Pop vitamin-A pills to protect yourself from heart attack: ATRA protects against myocardial ischemia/reperfusion injury via up regulation of its target gene, 4/March/2014, 8.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org; Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation
114. Pop vitamin-D pills to protect yourself from heart attack: 1,25-dihydroxy vitamin D protects against myocardial ischemia/reperfusion injury via up regulation of its target gene.; Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Pop vitamin-D pills to protect yourself from heart attack: 1,25-dihydroxy vitamin D protects against myocardial ischemia/reperfusion injury via up regulation of its target gene, 2/March/2014, 16.18, 2/March/2014, 16.19, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org; Courtesy: When you cite drop us a line at info@genomediscovery.org
115. Prof. Dr Robert I. Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA report in the prestigious journal Cell (2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer.” On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into cigarette smoking-mediated tumorigenesis: Cigarette smoking mediates wide spread suppression of miRNAs (in tumors) via up regulation of its target gene. Idea Proposed/Formulated by: Dr L Boominathan Ph.D.; Web: http://genomediscovery.org; Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/; To cite: Boominathan, Mechanistic insights into cigarette smoking-mediated tumorigenesis: Cigarette smoking mediates wide spread suppression of miRNAs (in tumors) via up regulation of its target gene, 19/March/2014, 7.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
