Publications

  • Research Publications: 
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  • Dr L Boominathan, the GBMD’s Founder Director-cum-Chief Scientist, has published more than 7500 bio-medical/pharma/therapeutic/clinical ideas (as of May/2015) at http://genomediscovery.org/category/ideas/ 

  • To the best of our knowledge, no scientist in the world has contributed to the development of 7500 bio-medical/pharma/therapeutic/clinical ideas related to Cancer, Cardiovascular disease (myocardial infarction, cardiomyopathy, cardiac hypertrophy), diabetes, hypertension, ageing, regenerative medicine, longevity, healthspan, neurodegenerative diseases, inflammatory diseases, bone related disorders etc. Visit this website  http://genomediscovery.org/ideas/bio-medical-ideas-1000/ to know more.
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  1. Vikhanskaya FToh WHDulloo IWu QBoominathan LNg HHVousden KHSabapathy K. p73 supports cellular growth through c-Jun-dependent AP-1 transactivation.Nat Cell Biol. 2007 Jun;9(6):698-705. Epub 2007 May 13.Impact factor: 19.407. The work is an integral part of Dr Boominathan’s Ph.D thesis [http://scholarbank.nus.edu/handle/10635/15006]
  2. Boominathan L.The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.Cancer Metastasis Rev. 2010 Dec;29(4):613-39.Impact factor: 10.573 (2011); The data discussed in this study was found to be reproduced recently in JAMA(Impact factor: 28.89; Fabbri et al., 2011 Jan 5;305(1):59-67); and The EMBO Journal (Impact factor: 8.993; Ugalde et al., Apr 26 2011). Most downloaded article of the year 2011-2012. Down load the articleBoominathanL-2010 The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network 
  3. Boominathan L.The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex.PLoS One. 2010 May 12;5(5):e10615.This is one of the most viewed articles in the miRNA and tumor suppressor genes field; The data presented in this study was found to be reproduced recently in Cell (Impact factor: ~31; Martello et al., Jun 25, 2010); Nature (Impact factor:~31.5; Xu et al., Oct 21, 2010); and J Clin Invest (Impact factor:15.38; Ory et al.,   Jan 10, 2011). Most viewed/read article of the year 2010-2011. Down load the articleThe Tumor Suppressors p53, p63, and p73 Are regulators of miRNA processing complex
  4. Boominathan L.Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors.Mol Cancer. 2007 Apr 3;6:27. Impact factor: 5.32 (2007); Down load the articleSome facts and thoughts p73 as a tumor suppressor gene in the network of tumor suppressors
  5. Toh WHSiddique MMBoominathan LLin KWSabapathy Kc-Jun regulates the stability and activity of the p53 homologue, p73.J Biol Chem. 2004 Oct 22;279(43):44713-22. Epub 2004 Aug 9.Impact factor: 5.328. Down load the articlec-Jun Regulates the Stability and Activity of the p53 homologue, p73This work is an integral part of Dr Boominathan’s Ph.D thesis [http://scholarbank.nus.edu/handle/10635/15006]
  6. Boominathan p63, p73, & p53 are negative regulators of epithelial to mesenchymal transition (EMT), invasion & metastasis Nature Precedings- 2009 – precedings.nature.com. The data presented in this study was found to be reproduced recently in Nature cell biology (Impact factor: 19.7; Chang et al., 20 Feb 2011); J Exp Med.  (Impact factor: 15.46; Kim et al., Apr 2011) ); Cell Death Differ. (Impact factor: 8.24; Magenta et al., Apr 2011); and Cell Research (Impact factor: 8.151; Schubert, Apr 2011)
  7. Boominathan Tumor suppressors function as a bottleneck against cellular reprogramming into iPS cells -Nature Precedings-2009 – precedings.nature.com
  8. Boominathan The TA-p73 functions as a Lung tumor suppressor by increasing the expression of miRNA, let-7 Nature Precedings– Nature Precedings -2010 – precedings.nature.com
  9. Boominathan Tumor suppressors p53, p63, and p73 inhibit migrating cancer stem cells by increasing the expression of stem cell suppressing miRNAs Nature Precidings- 2010 – precedings.nature.com
  10. Boominathan ∆ N-p63 functions as an invasion, migration, and metastasis suppressor Nature Precedings – 2010 – precedings.nature.com
  11. LP Boominathan Curcumin Functions as a Positive Regulator of miRNA Processing & a Negative Regulator of Cancer Stem Cell Proliferation Nature Precedings- 2009 – precedings.nature.com
  12. Boominathan The guardians of the genome dependent tumor suppressor miRNAs network Nature Precedings – 2009 – precedings.nature.com
  •  Research articles Submitted/submission in progress/In preparation:


  • Boominathan L, p53/TA-p63/p73 negatively regulates xxxx signal transduction pathway through its target miRNAs (Submitted)
  •  Boominathan L, The Tumor Suppressors p53, p63 and p73 function as Sentinels of Reprogramming   (Submitted)
  • Boominathan L, HIF therapeutics: Strategies: From stabilizers and repressors proteins to activators and inhibitors Book/Review (Submitted)
  • Boominathan L ∆N-p63 is an invasion, migration, and metastasis suppressor (Submitted)
  • Boominathan L A single xxxx targets a number of components in a biological Pathway (In preparation)
  • Boominathan L p53/TAp63/p73 regulates xxxx  through its target  miRNAs (In preparation)
  • Boominathan L p53, p63 and p73 regulate EMT, metastasis and Cancer stem cell proliferation (Inpreparation)
  • Boominathan L The tumor suppressors p53, p73 and p63 regulate xxxx stability through p53-miRs (In preparation)
  •  Boominathan L The TA-p73/p63-dependent tumor suppressor pathway  (In preparation)  
  • Boominathan L The p53/p63/p73 network links multiple tumor suppressor pathways (In preparation)
  • Boominathan L…. The p53 homologue, p63 plays a role in control of cell proliferation (In preparation)
  • Boominathan L Suppression of XXXX activity is required to induce TA p73/p63-dependent chemosensitivity (Submission in progress)
  • Boominathan L Toll signaling: How Turmeric functions as an anti-infective/diabetic/cancer agent (Submission in progress)
  •  Boominathan L XXXX controls cancer stem cell proliferation, tumorigenesis, and Reprogramming by regulating XXXX Regulator circuit (In preparation)
  • Boominathan L XXXX represses XXXX that suppress cancer stem cell (CSC) proliferation, while increases miRNAs that promote CSC proliferation.  (In preparation)
  • Boominathan L p53 and TA-p73/p63 regulate components of the XXXX machinery through their target miRNAs (In preparation)
  • Boominathan L The TA-p73/p63 functions as a XXXX tumor suppressor by increasing the expression of  XXXX (In preparation)
  • Boominathan L The tumor suppressors p53, p73 and p63 regulate XXXX stability through p53-miRs (In preparation)
  •  Boominathan L p53/p63/p73 regulates phosphorylation dependent stabilization of XXXX processing complex (In preparation)
  •  Boominathan L, and Sitkovsky M Regulation of HIF regulated pathways: What we know and what we need to know. Review (In preparation)
  • Boominathan L p53, TAp73, and TAp63 dependent miRNAs target XXXX proteins to increase the   apoptotic sensitivity of cancer cells (In preparation)
  • Boominathan L (One of the coauthors) & J. C. Schwamborn The p73-XXXX pathway plays an essential role in Neuronal stem cells proliferation & differentiation (Submitted)

  • Education-related Publications


  • Boominathan L Standardizing the standards of research in Universities in India (In preparation)
  • Boominathan L  Exemption from the requirement of a Successful guidance of minimum of one Ph.D. candidate for a Professor position in Universities (Submitted to Current Science)

  • Conference Publications/Papers/Posters: 


  1. Boominathan L, and Kanaga S, c-Jun is required for stabilization and activation of the p53-homologue, p73, 5th Beatson International Cancer Conference (sponsored by AARC), Glasgow, UK, from July 15th to 18th, 2001. Beatson cancer conference booklet cover0001; and Beatson International Cancer Conference0001
  2. Boominathan L, and Kanaga S, UV and Cisplatin-mediated p73 stabilization and p53-independent apoptosis require c-Jun. International p53 Workshop, Barcelona, Spain, from May 15to 18th , 2002. International p53 workshop bookelt cover0001; and International p53 workshop, Barcelona0001
  3. Kanaga S., Boominathan L, Vasantha MN, Lin K.W, UV-mediated p73 stabilization, resulting in p53-independent apoptosis.11th International p53 Workshop, Barcelona, Spain, from May 15to 18th , 2002.UV-mediated p73 stabilization, Int. p53 workshop0001
  4. Kanaga S and Boominathan L c-Jun is required for stabilization and activation of the p53-homologue, p73. 1st International p63/p73 workshop 2002, Rome, Italy, from June 10to11th, 2002. c-Jun promotes p73 stability p63.p73 workshop0001; and p63.p73 workshop cover page0001
  5. Kanaga S and Boominathan Lc-Jun is required for stabilization and activation of the p53-homologue, p73, Cancer Genetics & Tumor Suppressor Genes, Cold spring harbor laboratory, NY, USA, from August 14 –18th, 2002.  (Data presented in Poster no. 1 to 5 form the basis for obtaining an International patenthttp://www.google.com/patents/US20060127895?printsec=description&dq=Jun+p73&ei=bPXmT5jJOszIrQfc2ZT5CA#v=onepage&q=Jun%20p73&f=false by the Group leader.  Refer posters 1 to 5 to ascertain Dr Boominathan’s contributions. Its utility estimated to be in the range of US$ ONE billion/year  To quote their own words, “The potential market for such a drug could easily be in excess of US$ ONE billion/year.” Reference :  The Market value of Patent applied during Dr Boominathan’s tenure at NCC Singapore)
  6. L Boominathanp63, p73, and p53 are negative regulators of EMT, invasion and metastasis AICBC & International workshop on cell cycle regulation, 2009, Hyderabad, India.
  7. L Boominathan The guardians of the genome dependent tumor suppressor miRNAs networkAICBC & International workshop on cell cycle regulation, 2009, Hyderabad, India.
  8. L Boominathan Curcumin functions as a positive regulator of miRNA processing and a negative regulator of cancer stem cell proliferation.  Indo-US work shop on “Epigenetics and genomic regulation (with emphasis on RNAi & miRNA)”, 2009, Hyderabad, India.
  9. L Boominathan Tumor suppressors function as a bottleneck against cellular reprogramming into iPS cells, International conference on Emerging trends in Biotechnology, 2009, Varanasi, India.
  10. L Boominathan p53, p73, and p63 regulate alternative splicing by regulating components of Spliceosome machinery through their target miRNAs International Symposium on Frontiers in Carcinogenesis and Cancer prevention: Scientific endeavours and Public health initiatives, 2010, Mumbai, India.
  11.  L Boominathan The p73 functions as a Lung tumor suppressor by increasing the expression of miRNA, let-7 International conference in Cancer biology: Molecular mechanisms & therapeutics, 2010, Chennai, India
  12. L Boominathan Molecular Mechanistic insights into p73 and p63’s ability to function as tumor suppressorsInternational conference in Cancer biology: Molecular mechanisms & therapeutics, 2010, Chennai, India.
  13. L Boominathan p53, p73, and p63 inhibit Leukemic stem cell development through their target miRNAs29th Annual Convention of Indian association of cancer research and Symposium on Biology of Cancer Stem cells, 2010, Cochin, India.
  14. L Boominathan p53, p63, and p73 inhibit migrating cancer stem cells by activating stem cell suppressing miRNAs 29th Annual Convention of Indian association of cancer research and Symposium on Biology of Cancer Stem cells, 2010, Cochin, India.
  15. L Boominathan p73/p63/p53 functions as a mitotic checkpoint by negatively regulating AURKs and PLKs through its target miRNAs 29thAnnual Convention of Indian association of cancer research and Symposium on Biology of Cancer Stem cells, 2010, Cochin, India.
  16. L Boominathan The TA-p73/p63 functions as a lung/leukemia tumor          suppressor by increasing the expression of Downstream of Tyrosine     Kinases    genes.  International conference on frontiers in biological sciences (InCoFIBS) 2010, Rourkela, India. 
  17. L Boominathan Cigarette smoking represses p53/p73/p63-miRNAs that suppress cancer stem cell (CSC) proliferation, and increases miRNAs that promote CSC proliferation. International Conference on Stem cells and Cancer (ICSCC-2010), Pune, India. 
  18. L Boominathan  p53 and TA-p73/p63 regulate components of the epigenetic machinery through their target miRNAs.  International Conference on Stem cells and Cancer (ICSCC-2010), Pune, India.
  19. L Boominathan Activator protein-1 controls tumorigenesis, reprogramming, and CSC proliferation by regulating Lin-28-let-7 feedback circuit International Conference on Stem cells and Cancer (ICSCC-2010), Pune, India.
  20. L Boominathan Mechanisms through which p63/p73 functions as a tumor suppressor, Annual Convention of Indian Association of Cancer Research and Interanational symposium on Signalling network and cancer (IACR)-2011, Kolkata, India.
  21. L Boominathan Guardians of the genome (p53/p73/p63) function as regulators of happiness/depressionFrontiers in Carcinogenesis and Cancer Prevention: Scientific Advances and Public Health Initiatives, 2011, Bangalore, India
  22. L Boominathan p53/p63/p73-miRNAs function as Judges: Deciding between G1/G2-M phase arrest versus apoptosis International Conference on Stem cells and Cancer (ICSCC-2011), Pune, India.
  23. L Boominathan Guardians of the genome-p53, p63, and p73-function as regulators of Sleeping pattern and depression International Conference on Stem cells and Cancer (ICSCC-2011), Pune, India.
  24. L Boominathan Connection between the stress-induced oncosuppressor protein, p53 (p63/p73) and a regulator of pluripotencylin-28 in controlling the initiation of diabetes International Conference on Stem cells and Cancer (ICSCC-2011), Pune, India
  • Abstracts:


  1. L. Boominathanp53 family tumor suppressor network links multiple tumor suppressor pathways: p63/p73-dependent tumor suppressor pathways.  The Eighth International Conference of Anti-cancer research October 17-22, 2008 Kos, Greece.
  2. L Boominathan The concept of tumorsuppressome 29th Annual Convention of Indian association of cancer research and Symposium on Biology of Cancer Stem cells, 2010, Cochin, India.
  3. L Boominathan The tumor suppressors p73, p63 and p53 regulate asymmetric cell division and spindle-check point 29th Annual Convention of Indian association of cancer research and Symposium on Biology of Cancer Stem cells, 2010, Cochin, India.
  4. L Boominathan The tumor suppressors p53, TA-p73 and TA-p63 inhibit the expression of ∆NEx2p73 and ∆N-p63 through their target miRNAs International Symposium on Bioinformatics, 2010, Gujarat, India
  5. L Boominathan Molecular insight into Curcumin’s ability to function as an Anti-cancer/Inflammatory agent: Curcumin regulates Toll signaling through its targets p53/p73/p63, ATF3, and miRNAs International Symposium on Bioinformatics, 2010, Gujarat, India
  6. L Boominathan  p53/TAp63/p73 regulates c-Jun and c-fos family through its target miRNAs International Symposium on Bioinformatics, 2010, Gujarat, India.
  7. L Boominathan p53/TA-p63/p73 regulates c-Jun NH2-terminal   kinase signal transduction pathway through its target miRNAs, AICB conference, 2010, Kolkata, India.