Research Publications

  • Dr L Boominathan, the GBMD’s Founder Director-cum-Chief Scientist, has published more than 7500 bio-medical/pharma/therapeutic/clinical ideas (as of May/2015) at
  • To the best of our knowledge, no scientist in the world has contributed to the development of 7500 bio-medical/pharma/therapeutic/clinical ideas related to Cancer, Cardiovascular disease (myocardial infarction, cardiomyopathy, cardiac hypertrophy), diabetes, hypertension, ageing, regenerative medicine, longevity, healthspan, neurodegenerative diseases, bone related disorders etc. Visit this link to know more.
  1. Vikhanskaya FToh WHDulloo IWu QBoominathan LNg HHVousden KHSabapathy K. p73 supports cellular growth through c-Jun-dependent AP-1 transactivation.Nat Cell Biol. 2007 Jun;9(6):698-705. Epub 2007 May :13. Impact factor: 19.407. The work is an integral part of Dr Boominathan’s Ph.D thesis []
  2. Boominathan L.The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.Cancer Metastasis Rev. 2010 Dec;29(4):613-39. Impact factor: 10.573 (2011) The data discussed in this study was found to be reproduced recently in JAMA(Impact factor: 28.89; Fabbri et al., 2011 Jan 5;305(1):59-67); and The EMBO Journal (Impact factor: 8.993; Ugalde et al., Apr 26 2011). Most downloaded article of the year 2011-2012. 
  3. Boominathan L.The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One. 2010 May 12;5(5):e10615.This is one of the most viewed articles in the miRNA and tumor suppressor genes field; The data presented in this study was found to be reproduced recently in Cell (Impact factor: ~31; Martello et al., Jun 25, 2010); Nature (Impact factor:~31.5; Xu et al., Oct 21, 2010); and J Clin Invest (Impact factor:15.38; Ory et al.,   Jan 10, 2011). Most viewed/read article of the year 2010-2011. Gmail – Boominathan L The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex
  4. Boominathan L.Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors.              Mol Cancer. 2007 Apr 3;6:27. Impact factor: 5.32 (2007)
  5. Toh WHSiddique MMBoominathan LLin KWSabapathy Kc-Jun regulates the stability and activity of the p53 homologue, p73. J Biol Chem. 2004 Oct 22;279(43):44713-22. Epub 2004 Aug 9.Impact factor: 5.328. This work is an integral part of Dr Boominathan’s Ph.D thesis []
  6. Boominathan p63, p73, & p53 are negative regulators of epithelial to mesenchymal transition (EMT), invasion & metastasis Nature Precedings- 2009 – The data presented in this study was found to be reproduced recently in Nature cell biology (Impact factor: 19.7; Chang et al., 20 Feb 2011); J Exp Med.  (Impact factor: 15.46; Kim et al., Apr 2011) ); Cell Death Differ. (Impact factor: 8.24; Magenta et al., Apr 2011); and Cell Research (Impact factor: 8.151; Schubert, Apr 2011)
  7. Boominathan Tumor suppressors function as a bottleneck against cellular reprogramming into iPS cells -Nature Precedings-2009 –
  8. Boominathan The TA-p73 functions as a Lung tumor suppressor by increasing the expression of miRNA, let-7 Nature Precedings– Nature Precedings -2010 –
  9. Boominathan Tumor suppressors p53, p63, and p73 inhibit migrating cancer stem cells by increasing the expression of stem cell suppressing miRNAs Nature Precidings- 2010 –
  10. Boominathan ∆ N-p63 functions as an invasion, migration, and metastasis suppressor Nature Precedings – 2010 –
  11. LP Boominathan Curcumin Functions as a Positive Regulator of miRNA Processing & a Negative Regulator of Cancer Stem Cell Proliferation Nature Precedings- 2009 –
  12. Boominathan The guardians of the genome dependent tumor suppressor miRNAs network Nature Precedings – 2009 –
  •  Boominathan L, p53/TA-p63/p73 negatively regulates xxxx signal transduction pathway through its target miRNAs (Submitted)
  •  Boominathan L, The Tumor Suppressors p53, p63 and p73 function as Sentinels of Reprogramming   (Submitted)
  • Boominathan L, HIF therapeutics: Strategies: From stabilizers and repressors proteins to activators and inhibitors Book/Review (Submitted)
  • Boominathan L ∆N-p63 is an invasion, migration, and metastasis suppressor (Submitted)
  • Boominathan L A single xxxx targets a number of components in a biological Pathway (In preparation)
  • Boominathan L p53/TAp63/p73 regulates xxxx  through its target  miRNAs (In preparation)
  • Boominathan L p53, p63 and p73 regulate EMT, metastasis and Cancer stem cell proliferation (Inpreparation)
  • Boominathan L The tumor suppressors p53, p73 and p63 regulate xxxx stability through p53-miRs (In preparation)
  •  Boominathan L The TA-p73/p63-dependent tumor suppressor pathway  (In preparation)  
  • Boominathan L The p53/p63/p73 network links multiple tumor suppressor pathways (In preparation)
  • Boominathan L…. The p53 homologue, p63 plays a role in control of cell proliferation (In preparation)
  • Boominathan L Suppression of XXXX activity is required to induce TA p73/p63-dependent chemosensitivity (Submission in progress)
  • Boominathan L Toll signalingHow Turmeric functions as an anti-infective/diabetic/cancer agent (Submission in progress)
  •  Boominathan L XXXX controls cancer stem cell proliferation, tumorigenesis, and Reprogramming by regulating XXXX Regulator circuit (In preparation)
  • Boominathan L XXXX represses XXXX that suppress cancer stem cell (CSC) proliferation, while increases miRNAs that promote CSC proliferation.  (In preparation)
  • Boominathan L p53 and TA-p73/p63 regulate components of the XXXX machinery through their target miRNAs (In preparation)
  • Boominathan L The TA-p73/p63 functions as a XXXX tumor suppressor by increasing the expression of  XXXX (In preparation)
  • Boominathan L The tumor suppressors p53, p73 and p63 regulate XXXX stability through p53-miRs (In preparation)
  •  Boominathan L p53/p63/p73 regulates phosphorylation dependent stabilization of XXXX processing complex (In preparation)
  •  Boominathan L, and Sitkovsky M Regulation of HIF regulated pathways: What we know and what we need to know. Review (In preparation)
  • Boominathan L p53, TAp73, and TAp63 dependent miRNAs target XXXX proteins to increase the   apoptotic sensitivity of cancer cells (In preparation)
  • Boominathan L (One of the coauthors) & J. C. Schwamborn The p73-XXXX pathway plays an essential role in Neuronal stem cells proliferation & differentiation (Submitted)
  1.  Boominathan L GATE Qualified candidates & CSIR-NET UGC lectureship examination 2011, Current Science ISSN: 011-3891  GATE qualified candidates and NETCSIRUGC lectureship examination.
  2. Boominathan L Standardizing the standards of research in Universities in India (In preparation)
  3. Boominathan L Exemption from the requirement of a Successful guidance of minimum of one Ph.D. candidate for a Professor position in Universities (Submitted to Current Science)