A study from the Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Diabetes Unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; European Molecular Biology Laboratory, Mouse Biology Unit, 00015-Monterotondo, Italy; and Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK etc. shows that “IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.” This study was published in the 7 Apr 2015 issue of the journal “Cell Metabolism” [the number 1 journal in field of Metabolism with an I.F of 16.747] by Prof. Joseph Avruch, Ning Dai, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Scopoletin ameliorates T2DM & extends lifespan: Scopoletin, found in chicory, in Artemisia scoparia, in Stinging Nettle, and in the passion flower, increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene.
Significance: This study suggests, for the first time, that Scopoletin, by increasing the expression of its target gene, it may (1) decrease diet-induced obesity; (2) increase UCP protein expression;(3) increase energy expenditure; (4) increase cold tolerance; (5) increase glucose tolerance; (6) increase insulin sensitivity; and (7) extend lifespan. Thus, Scopoletin may ameliorate T2DM, promote lean mass, increase tolerance to cold exposure, and extend life span of an individual.
Undisclosed information: How Scopoletin increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and promotes longer lifespan
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Scopoletin ameliorates T2DM & extends lifespan: Scopoletin, found in chicory, in Artemisia scoparia, in Stinging Nettle, and in the passion flower, increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene, 8/May/2015, 22.50, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org