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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Small molecule-based Life-span extension therapy: Cardiotrophin-1 (CT-1) extends life span by down regulating the expression of  adenylate cyclase 5 (ADCY5), 30/March/2014, 9.35 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: It has been shown earlier that knocking down ADCY5/AC5 protects against diet-induced weight gain and insulin resistance. This study suggests, for the first time, that Cardiotrophin-1 (CT-1, by increasing the expression of its target gene,  it may suppress the expression of ADCY5/AC5. Thereby, it may (1) promote insulin sensitivity; (2) prevent diet-induced weight gain; (3) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing Cardiotrophin-1 (CT-1 activators (that suppress the expression of ADCY5/AC5) may be used to extend the life-span of an an individual.

Undisclosed information: How Cardiotrophin-1 (CT-1) suppresses the expression of  adenylate cyclase 5 (ADCY5)

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