Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: 17β-E2(An estrogen derivative) may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/April/2014, 8.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that 17β-E2, by increasing the expression of its target gene, it may suppress the expression of AT1R. And thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing ” 17β-E2 or its analogues” may be used to extend the life-span of an individual.
Undisclosed information: How 17β-E2 suppresses the expression of angiotensin II type I receptor (AT1R)