A recent study from the Department of Biology, McGill University, H3A 1B1, Montreal, Quebec, Canada shows that “Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.” This study was published in the 15 October 2005 issue of the journal “Genes & Development” (Impact factor: 12.44) by Prof Hekimi S, Liu X, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small RNA-based Lifespan extension therapy: MiRNA-495 promotes cellular fitness and life span via down regulation of its target gene
This study suggests, for the first time, a small RNA-based Lifespan extension therapy. MiRNA-200a, by decreasing the expression of its target gene mclk1, it may:(1) increase cellular fitness; and (2) extend lifespan. Thus, pharmacological formulations encompassing “MiRNA-200a or its activators“ may be used to increase cellular fitness; and extend lifespan.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Small RNA-based Lifespan extension therapy: MiRNA-200a promotes cellular fitness and extends life span via down regulation of its target gene, 28/April/2014, 14.48, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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