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A recent study from the Department of Biology, McGill University, H3A 1B1, Montreal, Quebec, Canada shows that “Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.” This study was published in the 15 October  2005 issue of the journal “Genes & Development” (Impact factor: 12.44) by Prof Hekimi SLiu X, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small RNA-based Lifespan extension therapy: MiRNA-495 promotes cellular fitness and life span via down regulation of its target gene


This study suggests, for the first time, a small RNA-based Lifespan extension therapy. MiRNA-200a, by decreasing the expression of its target gene mclk1, it may:(1) increase cellular fitness; and (2) extend lifespan.  Thus, pharmacological formulations encompassing MiRNA-200a or its activators may be used to increase cellular fitness; and extend lifespan.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Small RNA-based Lifespan extension therapy: MiRNA-200a promotes cellular fitness and extends life span via down regulation of its target gene, 28/April/2014, 14.48,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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