- A study from the Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain has reported that “The transcription factor GATA Binding Protein-6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.”
- This study was published in the 22 June 2014 Nature Cell Biology by Prof. Eduard Batlle, Gavin Whissell, and others from the Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: MiRNA--based therapy for Colorectal cancer: MiRNA-363 inhibits self-renewal of colon adenoma cells by increasing BMP gene expression. This study suggests that MiRNA-363, by decreasing the expression of its target gene, it could inhibit the self-renewal of colon adenoma cells. Taken together, this study suggests that pharmacological formulations containing “miR-363 or its activator” can be used to inhibit the initiation and progression of colorectal carcinoma.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, MiRNA-based therapy for Colorectal cancer: MiRNA-363 inhibits self-renewal of colon adenoma cells by increasing BMP gene expression, 11/July/2014, 13.37, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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