Small RNAs not only cure T2DM but also extend lifespan: MiRNA-335 increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and extends lifespan via down regulation of its target gene, 4/May/2015, 22.56

A study from the Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Diabetes Unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; European Molecular Biology Laboratory, Mouse Biology Unit, 00015-Monterotondo, Italy; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK etc.   shows that “IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.” This study was published in the 7 Apr  2015 issue of the journal “Cell Metabolism” [the number 1 journal in field of Metabolism with an I.F of 16.747] by Prof. Joseph Avruch, Ning Dai,  and Others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small RNAs not only cure T2DM but also extend lifespan: MiRNA-335 increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and extends lifespan via down regulation of its target gene. 

Significance: This study suggests, for the first time, that MiRNA-335, by decreasing the expression of its target gene, it may decrease diet-induced obesity, increase UCP protein expression, energy expenditure, cold tolerance, glucose tolerance, insulin sensitivity and extend lifespan.  Thus, pharmacological formulations encompassing “MiRNA-335 or its activators” may be used to treat T2DM, promote lean mass, increase cold exposure tolerance and extend the life span of an individual.

Undisclosed information: How MiRNA-335 increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and promotes longer lifespan

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To cite: Boominathan, Small RNAs not only cure T2DM but also extend lifespan:   MiRNA-335 increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and extends lifespan via down regulation of its target gene, 4/May/2015,  22.56,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org