Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Significance: This study suggests a vitamin-based Anti-metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, it may increase the expression of tumor suppressor PTEN. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing ” Calcitriol or its analogues” may be used to inhibit the progression of invasive tumors. Given that exposure to Sunlight increases the levels of 1,25-dihydroxyvitamin D, one may expose to the optimal level of sunlight to stall cancer progression.
Undisclosed information: How Calcitriol increases the expression of PTEN
Citation: Boominathan, L., Stalling metastatic cancer spread by exposing it to the Sunlight: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor PTEN and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 4/May/2015, 22.49, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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